IBR2 - Moligand™,10mM in DMSO , CAS No.313526-24-8

CAS: 313526-24-8 Cat. No.: I654536 Molecular Weight: 400.5 PubChem CID: 4664423

GRADE & PURITY Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis

In Vitro

IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC 50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines. IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with an IC 50 of 14.8 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:RAD51

Specifications

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

IBR2 is a potent and specific RAD51 inhibitor and inhibits RAD51 -mediated DNA double-strand break repair. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, inhibits cancer cell growth and induces apoptosis [1

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)CS(=O)(=O)N2C=CC3=CC=CC=C3C2C4=CNC5=CC=CC=C54
• PubChem CID: 4664423
• Molecular Weight: 400.5