Iodoacetamide - Moligand™, ≥98% , Activator of TRPA1, CAS No.144-48-9, Activator of TRPA1

CAS: 144-48-9 Cat. No.: I105563 Formula: C2H4INO Molecular Weight: 184.96 Beilstein Registry Number: 1739080 EC Number: 205-630-1
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
Synonyms
A808220 | Iodoacetamide, >=98.0% (AT), purum | Iodoacetamide, Single use vial of 56 mg | SCHEMBL20371 | 1219802-64-8 | PGLTVOMIXTUURA-UHFFFAOYSA- | WLN: ZV1I | BDBM50376514 | GTPL6271 | IODOACETAMIDE-D4 | NCGC00015548-06 | NCGC00093954-01 | alpha-Iodoacet
Storage
Store at 2-8°C,Protected from light
Shipped In
Wet ice
★
Size
Germany (EU)
USA*
Price
Qty
5g
I105563-5g
—
8 In stock

€9.46

€14.66
Save €5.21 (35.50%)
10g
I105563-10g
Made to order · 8–12 wks

€16.40

€25.08
Save €8.68 (34.60%)
25g
I105563-25g
—
6 In stock

€36.36

€54.58
Save €18.22 (33.39%)
100g
I105563-100g
Made to order · 8–12 wks

€117.06

€176.06
Save €59.01 (33.51%)
500g
I105563-500g
—
1 In stock

€436.39

€655.06
Save €218.67 (33.38%)
Enter a quantity for the sizes you want to add.
🧪
Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at 2-8°C,Protected from light Ships Wet ice Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 112 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Alkylating reagent for cysteine residues in peptide sequencing.

Specifications

Synonyms
A808220 | Iodoacetamide, >=98.0% (AT), purum | Iodoacetamide, Single use vial of 56 mg | SCHEMBL20371 | 1219802-64-8 | PGLTVOMIXTUURA-UHFFFAOYSA- | WLN: ZV1I | BDBM50376514 | GTPL6271 | IODOACETAMIDE-D4 | NCGC00015548-06 | NCGC00093954-01 | alpha-Iodoacet
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for
Storage
Store at 2-8°C,Protected from light
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ACTIVATOR
Mechanism of action
Activator of TRPA1
Purity
≥98%
Names and Identifiers
Pubchem Sid
Pubchem Sid Url
https://pubchem.ncbi.nlm.nih.gov/substance/508815490
Canonical Smiles
C(C(=O)N)I
IUPAC Name
2-iodoacetamide
InChIKey
PGLTVOMIXTUURA-UHFFFAOYSA-N
INCHI
1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
Isomeric SMILES
C(C(=O)N)I
WGK Germany
3
RTECS
AC4200000
UN Number
2811
Packing Group
III
Molecular Weight
184.96
Beilstein
1739080
Reaxy-Rn
1739080
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1739080&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

<<<<<<< HEAD Download SDS → ======= Download SDS → >>>>>>> release248-p3

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassCarboxylic acid derivatives
Intermediate Tree Nodes Carboxylic acid amides
Direct ParentPrimary carboxylic acid amides
Alternative Parents Organopnictogen compounds  Organonitrogen compounds  Organoiodides  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  Alkyl iodides  
Molecular FrameworkAliphatic acyclic compounds
Substituents Primary carboxylic acid amide - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Organoiodide - Organohalogen compound - Carbonyl group - Alkyl iodide - Alkyl halide - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as primary carboxylic acid amides. These are compounds comprising primary carboxylic acid amide functional group, with the general structure RC(=O)NH2.
External Descriptors an iodide
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
CYP3A4 Tclin Cytochrome P450 3A4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TYMS Tclin Thymidylate synthase (1651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AK2 Tbio Adenylate kinase 2 (264 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F13A1 Tchem Coagulation factor XIII (223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 (8818 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THPO Tbio Thrombopoietin (834 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATG4B Tchem Cysteine protease ATG4B (985 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADH1A Tclin Alcohol dehydrogenase (35 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Associated Targets(non-human)
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
crtY Lycopene cyclase (9 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates (CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

61 results found

Lot NumberCertificate TypeDateItem
H2612705H2612705Certificate of AnalysisJun 22, 2026 I105563
H2612706H2612706Certificate of AnalysisJun 22, 2026 I105563
H2612707H2612707Certificate of AnalysisJun 22, 2026 I105563
H2612708H2612708Certificate of AnalysisJun 22, 2026 I105563
G2607018G2607018Certificate of AnalysisMay 06, 2026 I105563
H2605006H2605006Certificate of AnalysisMay 06, 2026 I105563
D2630375D2630375Certificate of AnalysisMay 06, 2026 I105563
D2630424D2630424Certificate of AnalysisMay 06, 2026 I105563
D2630425D2630425Certificate of AnalysisMay 06, 2026 I105563
D2630426D2630426Certificate of AnalysisMay 06, 2026 I105563
D2630427D2630427Certificate of AnalysisMay 06, 2026 I105563
H2613018H2613018Certificate of AnalysisMay 06, 2026 I105563
J2531444J2531444Certificate of AnalysisNov 03, 2025 I105563
J2531370J2531370Certificate of AnalysisNov 03, 2025 I105563
J2531420J2531420Certificate of AnalysisNov 03, 2025 I105563
J2531441J2531441Certificate of AnalysisNov 03, 2025 I105563
I2506008I2506008Certificate of AnalysisJun 24, 2025 I105563
F2518411F2518411Certificate of AnalysisJun 24, 2025 I105563
F2518410F2518410Certificate of AnalysisJun 24, 2025 I105563
F2518409F2518409Certificate of AnalysisJun 24, 2025 I105563
F2518408F2518408Certificate of AnalysisJun 24, 2025 I105563
F2518379F2518379Certificate of AnalysisJun 24, 2025 I105563
F2518380F2518380Certificate of AnalysisJun 24, 2025 I105563
L2406530L2406530Certificate of AnalysisOct 22, 2024 I105563
L2406462L2406462Certificate of AnalysisOct 22, 2024 I105563
L2406463L2406463Certificate of AnalysisOct 22, 2024 I105563
L2406464L2406464Certificate of AnalysisOct 22, 2024 I105563
F2411238F2411238Certificate of AnalysisMay 16, 2024 I105563
F2411237F2411237Certificate of AnalysisMay 16, 2024 I105563
F2411236F2411236Certificate of AnalysisMay 16, 2024 I105563
I2406219I2406219Certificate of AnalysisMay 16, 2024 I105563
F2411239F2411239Certificate of AnalysisMay 16, 2024 I105563
E2408061E2408061Certificate of AnalysisNov 17, 2023 I105563
K2330108K2330108Certificate of AnalysisNov 17, 2023 I105563
K2330110K2330110Certificate of AnalysisNov 17, 2023 I105563
K2330112K2330112Certificate of AnalysisNov 17, 2023 I105563
K2330114K2330114Certificate of AnalysisNov 17, 2023 I105563
I2304340I2304340Certificate of AnalysisAug 18, 2023 I105563
I2304350I2304350Certificate of AnalysisAug 18, 2023 I105563
I2304385I2304385Certificate of AnalysisAug 18, 2023 I105563
F2305295F2305295Certificate of AnalysisMay 24, 2023 I105563
F2305294F2305294Certificate of AnalysisMay 24, 2023 I105563
F2305296F2305296Certificate of AnalysisMay 24, 2023 I105563
D2418049D2418049Certificate of AnalysisMay 24, 2023 I105563
F2305292F2305292Certificate of AnalysisMay 10, 2023 I105563
F2305285F2305285Certificate of AnalysisMay 10, 2023 I105563
F2305293F2305293Certificate of AnalysisMay 10, 2023 I105563
G2311061G2311061Certificate of AnalysisMay 10, 2023 I105563
D2320040D2320040Certificate of AnalysisNov 21, 2022 I105563
K2224520K2224520Certificate of AnalysisNov 21, 2022 I105563
K2224518K2224518Certificate of AnalysisNov 21, 2022 I105563
K2224517K2224517Certificate of AnalysisNov 21, 2022 I105563
K2224516K2224516Certificate of AnalysisNov 21, 2022 I105563
E2310060E2310060Certificate of AnalysisNov 21, 2022 I105563
H2215147H2215147Certificate of AnalysisJun 05, 2022 I105563
H2215146H2215146Certificate of AnalysisJun 05, 2022 I105563
H2215145H2215145Certificate of AnalysisJun 05, 2022 I105563
H2215144H2215144Certificate of AnalysisJun 05, 2022 I105563
F2201266F2201266Certificate of AnalysisMay 24, 2022 I105563
E2220212E2220212Certificate of AnalysisMay 24, 2022 I105563
C2208137C2208137Certificate of AnalysisMar 15, 2022 I105563
Chemical and Physical Properties
SolubilitySoluble in water; Soluble in Methanol
SensitivityLight & Moisture Sensitive
Melt Point(°C)95°C
Molecular Weight184.960 g/mol
XLogP3-0.200
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count1
Exact Mass184.934 Da
Monoisotopic Mass184.934 Da
Topological Polar Surface Area43.100 Ų
Heavy Atom Count5
Formal Charge0
Complexity44.900
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Common Reagents for Reducing Protein Disulfide Bonds
A Practical Guide to Small-Molecule Chemical Probes: Concept Clarification, Causal Validation, and Experimental Selection (with Product Navigation and Tables A–D)
Endoproteinase Lys-C: Mechanism, Applications, and Method-Control Considerations for Lysine-Specific Digestion
Plant Omics Panorama: Workflow Frameworks and Multi-Omics Integration from Genomics to Transcriptomics, Proteomics, and Metabolomics
Bromelain: Enzymological Properties and Key Points for Food, Pharmaceutical, and Industrial Applications
Methionine: Biological Roles and Key Points for Research Application
Review of Chymotrypsin: Enzymological Properties, Catalytic Mechanism, and Research Applications
Clostridial Proteases: Classification, Molecular Mechanisms, and Research Applications
Glycoprotein Hormone Family: Molecular Features, Signaling Bias, and In Vivo Pharmacokinetics
Methodological Studies on Glycoprotein Structural Characterization and Quality Attribute Analysis
Research Framework for Multi-Enzyme Digestion Strategies and Optimization of Proteomic Coverage
Thiol and Disulfide Status in Biological Samples: Detection Methods and Applications
Neuropathological Mechanisms of Cerebral Infarction
Summary of Research Advances in Oxidative Stress
Regulatory Mechanisms, Research Methods, and Modification-Omics Analysis of Protein Post-Translational Modifications
Why Proximity to Cysteine Does Not Necessarily Lead to Covalent Bond Formation: Warhead Reactivity, Reaction Geometry, and Target-Site Microenvironment
Citations of This Product
Solution Calculators
Reviews

Customer Reviews

Shall we send you a message when we have discounts available?

Remind me later

Thank you! Please check your email inbox to confirm.

Oops! Notifications are disabled.