"}
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K i and an EC 50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor.
| CAS | 1215192-68-9 |
|---|---|
| Concentration | 10 mM in DMSO |
| Specifications & Purity | Moligand™, 10 mM in DMSO |
| Storage | Argon charged,Store at -80°C |
| Shipped In | Dry ice packs + Cold packs |
| Product Description | KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K i and an EC 50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor. |