KN-93 - Moligand™, 10mM in DMSO , Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit, CAS No.139298-40-1, Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

CAS: 139298-40-1 Cat. No.: K421478 Molecular Weight: 599.03

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM).
An effective inhibitor of CaMKII phosphorylating activity

Specifications

Synonyms

AMY3402 | (2-[N -(2-hydroxyethyl)]-N -(4-methoxybenzenesulfonyl)]amino-N -(4-chlorocinnamyl)-N -methylbenzylamine) | AKOS015994570 | BCP9000817 | J-007263 | NCGC00162399-02 | SCHEMBL14569460 | N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}me

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to i

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of calcium/calmodulin-dependent protein kinase II alpha subunit

Names and Identifiers

• Isomeric SMILES: CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
• WGK Germany: 3
• Molecular Weight: 599.03
• Reaxy-Rn: 8357363
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8357363&ln=

Associated Targets(Human)

CAMK2A Tchem Calcium/calmodulin-dependent protein kinase type II subunit alpha (1 Activities)

Discover Target: CAMK2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Sensitivity: Heat Sensitive
• Refractive Index: 1.63
• Boil Point(°C): 657.60° C at 760 mmHg

References

1. Jinpeng Lv, Ximei Zhang, Xiaohong An, Yan Cao, Duo Meng, Kun Zou, Rongyin Gao, Ruzhi Zhang.  (2023)  The inhibition of VDAC1 oligomerization promotes pigmentation through the CaMK–CRTCs/CREB–MITF pathway.  EXPERIMENTAL CELL RESEARCH,      [PMID:38070860] [10.1016/j.yexcr.2023.113874]

2. Yuqian Chen, Jin Liu, Qianqian Zhang, Limin Chai, Huan Chen, Danyang Li, Yan Wang, Yuanjie Qiu, Nirui Shen, Jia Zhang, Qingting Wang, Jian Wang, Xinming Xie, Shaojun Li, Manxiang Li.  (2024)  Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:38479721] [10.1016/j.ejphar.2024.176483]