KRN2 bromide - ≥98% , CAS No.1390654-28-0

CAS: 1390654-28-0 Cat. No.: K647849 Formula: C₂₇H₂₃BrFNO₄ Molecular Weight: 524.38

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5) , with an IC 50 of 0.1 μM.

In Vitro

KRN2 selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hampering high-salt-induced NFAT5 and its target gene expressions. KRN2 dose-dependently inhibits the NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KRN2 (3 mg/kg, i.p., daily for 2 weeks) effectively suppresses AIA in which innate immune cells play a predominant role . KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-week-old C57BL/6 mice injected intradermally with 2 mg of complete Freund's adjuvant . Dosage: 3 mg/kg. Administration: Peritoneally (i.p.) daily for 2 weeks. Result: Effective in suppressing AIA. Animal Model: 8-week-old DBA/1Jmice immunized with bovine type II collagen . Dosage: 3 mg/kg. Administration: Peritoneally (i.p.) daily. Result: Effective in suppressing CIA as well as AIA in mice, decreasing the production of pro-inflammatory cytokines and autoantibodies as well as macrophage infiltration.

Form:Solid

IC50& Target:IC50: 100 nM (NFAT5)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5) , with an IC 50 of 0.1 μM.

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: COC1=C(OC)C2=C[N+]3=C(C(C(CC3)=C4)=CC5=C4OCO5)C(CC6=CC=CC=C6F)=C2C=C1.[Br-]
• Molecular Weight: 524.38

Chemical and Physical Properties

• Solubility: DMSO : 18.33 mg/mL (34.96 mM; Need ultrasonic) H2O : 1.1 mg/mL (2.10 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1390654-28-0, the molecular formula is C27H23BrFNO4, and the molecular weight is 524.38 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.