KS100 , CAS No.2408477-54-1

CAS: 2408477-54-1 Cat. No.: K651452 Formula: C₁₇H₁₄Br₃N₃O₂S Molecular Weight: 564.09

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2 , and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase

In Vitro

KS100 (compound 3j) (0-100 µM; 72 h) shows anti-proliferative activity with IC 50 s of 3.7, 2.1, 2.9, 2.5, 0.3, 1.0, 1.2, 1.3, 2.1, 9.8 µM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively. KS100 (5 µM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: HCT116, HT29 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell apoptosis. Apoptosis AnalysisCell Line: HCT116 cells Concentration: 5 µM Incubation Time: 24 h Result: Induced cell cycle arrest at G2/M phase.

Form:Solid

IC50& Target:IC 50 : 230 nM (ALDH1A1),1542 nM (ALDH2),193 nM (ALDH3A1)

Specifications

Biochemical and Physiological Mechanisms

KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2 , and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 564.09

Chemical and Physical Properties

• Solubility: DMSO : 125 mg/mL (221.60 mM; Need ultrasonic)

Frequently Asked Questions

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2408477-54-1, the molecular formula is C17H14Br3N3O2S, and the molecular weight is 564.09 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.