By Target / Pathway / Disease

Explore small molecules, screening libraries, and tool compounds for discovery research. Browse by target, pathway, or ligand family to quickly find inhibitors, agonists, and chemical probes, with searchable structure/CAS data and supporting documents (SDS/COA where available).

136,942 products

Ready-to-screen compound libraries and focused sets for hit discovery. Browse libraries by target class, pathway, scaffold, or application, and review size, format, and compound information to build screening panels.Customize Your Screening Library to choose compounds, format, and volume, and we’ll prepare a ready-to-use set for you.Customize Your Screening Library

Navigate small molecules by ligand family or scaffold to build focused sets and explore structure–activity relationships. This category groups related chemotypes, helping you select analogs, fragments, and tool molecules for discovery research.

ADC-focused building blocks and tools to support antibody–drug conjugate research. Explore payloads, linkers, conjugation reagents, and related small-molecule components (where available) for designing and evaluating ADC constructs.

PROTAC

2,814

PROTAC and targeted protein degradation tools for discovery research. Browse degrader-related ligands, linkers, and building blocks (where available) to assemble or screen PROTAC designs, with clear identifiers for efficient selection.

Explore pathway-focused tool compounds to study and modulate key signaling cascades. Browse small molecules grouped by signaling pathway to support mechanism studies, phenotypic assays, and target validation, with clear identifiers for fast searching.

Find bioactive small molecules organized by protein target (DTO). Quickly locate tool compounds for specific targets and compare identifiers such as structure, CAS, and synonyms—plus supporting documents —to build screening and validation sets.

Shop small molecules and tool compounds organized by disease area (DOID). Discover chemical probes, libraries, and related products mapped to therapeutic areas to help assemble compound sets for screening, pathway exploration, and model studies.

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  1. α-helical CRF 9-41
    CAS: 90880-23-2 PubChem CID: 44593730 Formula: C166H274N46O53S2 Molecular Weight: 3826.40
    ● In Stock — US warehouse, ships to EU* Item #: H287574
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    SMILES
    [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(Cshow more
    InChIKey
    PNGVJHODDQMQKT-GVKLFNHCSA-N
    Synonyms
    α-helical-Corticotropin-Releasing Factor 9-41
  2. β-Amyloid (1-40) (TFA)
    CAS: 131438-79-4(free) Formula: C194H295N53O58S·XC2HF3O2 Molecular Weight: 4329.82(free base)
    ● In Stock — US warehouse, ships to EU* Item #: A488870
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    Bioactivity
    β-Amyloid (1-40) TFA is a primary protein in plaques found in the brains of patients with Alzheimer's disease。
    Synonyms
    Amyloid Beta-Peptide (1-40) (human) TFA | Amyloid β-Peptide (1-40) (human) TFA)
  3. [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA
    CAS: 137565-28-7(free) Formula: C41H66F3N9O11 Molecular Weight: 918.01
    ● In Stock — US warehouse, ships to EU* Item #: L488917
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    (3S,4Z,6S,7Z,9S,10Z,12S,13Z,18S,19Z,21S)-3-amino-6-(4-aminobutyl)-9-benzyl-4,7,10,13,19-pentahydroxy-21-(hydroxy(imin...
  4. tcY-NH2
    CAS: 327177-34-4 PubChem CID: 11479675 Formula: C40H49N7O7 Molecular Weight: 739.87
    ◐ .Made to order · 8–12 wks Item #: T287815
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    IUPAC Name
    (2S)-N-[2-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-1-[(2S)-3-(4-hydroxyphenyl)-2-[[(E)-3-phshow more
    SMILES
    C1CC(N(C1)C(=O)C(CC2=CC=C(C=C2)O)NC(=O)C=CC3=CC=CC=C3)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC4=CC=CC=C4)C(=O)N
    InChIKey
    XKRAKQXQVIGYQC-PHOSSJRVSA-N
    InChI
    1S/C40H49N7O7/c41-22-8-7-14-31(38(52)46-32(37(42)51)24-28-12-5-2-6-13-28)44-36(50)26-43-39(53)34-15-9-23-47(34)40(54)33(25-29-16-19-30(48)20-17-29)45-show more
    Synonyms
    (trans-Cinnamoyl)-YPGKF-NH2
  5. α-Dendrotoxin TFA salt
    CAS: 74504-53-3(free base) Formula: C305H480N98O85S6(free base) Molecular Weight: 7072.07(free base)
    ● In Stock — US warehouse, ships to EU* Item #: D335128
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    Synonyms
    Toxin C13S2C3 | Toxin C-S2-C | alpha-Dendrotoxin
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R&D Use Only Products supplied for research and development use

Frequently Asked Questions

What does the By Target/Pathway/Disease listing cover?
It groups compounds associated with targets in By Target/Pathway/Disease, organised so you can move from the pathway to an individual target and then to a specific chemotype. Each entry carries structure, CAS number, and reported activity.
How is By Target/Pathway/Disease organised?
By Target/Pathway/Disease is broken down into Compound Libraries, PROTACs, molecular glues and other degraders and Antibody-drug Conjugates(ADC). Compounds acting on more than one node appear under each relevant target.
How do I choose compounds for By Target/Pathway/Disease research?
For By Target/Pathway/Disease, pick a well-characterised reference compound for the node you want to perturb, and pair it with a structurally unrelated compound hitting the same target — that is the cleanest way to separate pathway effects from off-target ones. Check potency, selectivity, and cell permeability against your assay format. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find a specific compound within By Target/Pathway/Disease?
Search By Target/Pathway/Disease by compound name, CAS number, or SMILES, or drill down through the target listing. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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