Ly93 - ≥99% , CAS No.1883528-69-5

CAS: 1883528-69-5 Cat. No.: L647031 Formula: C₂₁H₂₀N₂O₂ Molecular Weight: 332.40 EC Number: 839-503-2 PubChem CID: 118911741

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC 50 of 91 nM.

In Vivo

Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice . Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6J mice . Dosage: 100 mg/kg. Administration: I.G. (gavage) once daily for 7 days. Result: Significantly decreased the plasma SM levels compared with vehicle group. Animal Model: ApoE KO mice (eight-week-old) . Dosage: 12.5 or 40 mg/kg. Administration: I.G. (gavage) once daily. Result: The levels of ALT and AST in the plasma of apoE KO mice did not show statistic changes when compared with the control group.

Form:Solid

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC 50 of 91 nM.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Isomeric SMILES

CCC1=CC=CC=C1COC2=CC=CC=C2C(=O)NC3=CN=CC=C3

PubChem CID

118911741

Molecular Weight

332.40

Associated Targets(Human)

SGMS2 Tchem Phosphatidylcholine:ceramide cholinephosphotransferase 2 (2 Activities)

Discover Target: SGMS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SGMS2 Tchem Phosphatidylcholine:ceramide cholinephosphotransferase 2 (194 Activities)

Discover Target: SGMS2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
• Molecular Weight: 332.400 g/mol
• XLogP3: 3.900
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 332.152 Da
• Monoisotopic Mass: 332.152 Da
• Topological Polar Surface Area: 51.200 Ų
• Heavy Atom Count: 25
• Formal Charge: 0
• Complexity: 415.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1883528-69-5, the molecular formula is C21H20N2O2, and the molecular weight is 332.40 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.