MAC glucuronide linker-2 - Moligand™, ≥99% , CAS No.229977-57-5

CAS: 229977-57-5 Cat. No.: M649497 Molecular Weight: 455.42

GRADE & PURITY Moligand™, ≥99%

Synonyms

Methyl 2-Amino-4-(hydroxymethyl)phenyl 2,3,4-tri-O-acetyl-β-D-glucuronate | 2-Amino-4-(hydroxymethyl)phenyl 2,3,4-tri-O-acetyl-β-D-glucuronic Acid Methyl Ester

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Overview

MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

Form:Solid

IC50& Target:Cleavable Glycosidase Cleavable

Specifications

Synonyms

Methyl 2-Amino-4-(hydroxymethyl)phenyl 2, 3, 4-tri-O-acetyl-β-D-glucuronate | 2-Amino-4-(hydroxymethyl)phenyl 2, 3, 4-tri-O-acetyl-β-D-glucuronic Acid Methyl Ester

Specifications & Purity

Moligand™, ≥99%

Biochemical and Physiological Mechanisms

MAC glucuronide linker-2 is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Storage

Store at -20°C, Argon charged, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC(=O)OC1C(C(OC(C1OC(=O)C)OC2=C(C=C(C=C2)CO)N)C(=O)OC)OC(=O)C
• IUPAC Name: methyl (2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[2-amino-4-(hydroxymethyl)phenoxy]oxane-2-carboxylate
• InChIKey: ZAZPQJAJSIUIEY-KVIJGQROSA-N
• INCHI: 1S/C20H25NO11/c1-9(23)28-15-16(29-10(2)24)18(30-11(3)25)20(32-17(15)19(26)27-4)31-14-6-5-12(8-22)7-13(14)21/h5-7,15-18,20,22H,8,21H2,1-4H3/t15-,16-,17-,18+,20+/m0/s1
• Isomeric SMILES: CC(=O)O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1OC(=O)C)OC2=C(C=C(C=C2)CO)N)C(=O)OC)OC(=O)C
• Molecular Weight: 455.42

Chemical and Physical Properties

• Solubility: DMSO : 200 mg/mL (439.16 mM; Need ultrasonic)
• Sensitivity: Moisture sensitive，Air sensitive，Heat sensitive
• Melt Point(°C): 138.0-142.0 °C
• Molecular Weight: 455.400 g/mol
• XLogP3: -0.100
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 11
• Exact Mass: 455.143 Da
• Monoisotopic Mass: 455.143 Da
• Topological Polar Surface Area: 170.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 699.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1