Magnolol - 10mM in DMSO , CAS No.528-43-8

CAS: 528-43-8 Cat. No.: M407956 Formula: C₁₈H₁₈O₂ Molecular Weight: 266.33 Beilstein Registry Number: 6(4)6918 EC Number: 610-903-7

GRADE & PURITY 10mM in DMSO

Synonyms

NSC 293099 | [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Magnolol Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.
In vitro

Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABA_A receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

In vivo

LD50: Mice 2200mg/kg (i.g.).
Cell Data

cell lines：LNCaP/AR prostate cancer cell line

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

NSC 293099 | [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Magnolol (NSC 293099) is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. It can block TNF-α-induced NF-KB activation.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Isomeric SMILES

C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O

WGK Germany

3

RTECS

DV5105500

UN Number

3077

Molecular Weight

266.33

Beilstein

6(4)6918

Reaxy-Rn

1982224

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1982224&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 100 mg/mL (148.9 mM); Ethanol: 4 mg/mL (5.95 mM); Water: Insoluble
• Boil Point(°C): 180 °C/1 mmHg
• Melt Point(°C): 101 °C

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 528-43-8, the molecular formula is C18H18O2, and the molecular weight is 266.33 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.