Maleimide - ≥98% , CAS No.541-59-3

Name: Maleimide - ≥98% , CAS No.541-59-3
SKU: M100788
Availability: InStock

CAS: 541-59-3 Cat. No.: M100788 Formula: C₄H₃NO₂ Molecular Weight: 97.07 Beilstein Registry Number: 106910 EC Number: 208-787-4

10 Citations COA

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Maleimide - ≥98% CAS No(541-59-3) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

Storage

Room temperature

Shipped In

Normal

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Normal Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 10 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Maleimide (2,5-Pyrroledione) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.
The maleimide-functionalized silica beads were used to immobilize the bovine serum albumin (BSA)-boronic acid (BA) conjugates.

Specifications

Synonyms

Specifications & Purity

≥98%

Storage

Room temperature

Shipped In

Normal

Purity

≥98%

Names and Identifiers

Pubchem Sid

508817126

Canonical Smiles

C1=CC(=O)NC1=O

IUPAC Name

pyrrole-2,5-dione

InChIKey

PEEHTFAAVSWFBL-UHFFFAOYSA-N

INCHI

1S/C4H3NO2/c6-3-1-2-4(7)5-3/h1-2H,(H,5,6,7)

Isomeric SMILES

C1=CC(=O)NC1=O

WGK Germany

RTECS

ON4800000

UN Number

2923

Molecular Weight

97.07

Beilstein

106910

Reaxy-Rn

106910

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=106910&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Pyrrolidines
    - Subclass Pyrrolidones

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Pyrrolidines
Subclass	Pyrrolidones
Intermediate Tree Nodes	Not available
Direct Parent	Maleimides
Alternative Parents	Pyrrolines N-unsubstituted carboxylic acid imides Dicarboximides Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteromonocyclic compounds
Substituents	Maleimide - Carboxylic acid imide - Dicarboximide - Carboxylic acid imide, n-unsubstituted - Pyrroline - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aliphatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as maleimides. These are compounds containing a 2,5-pyrroledione moiety.
External Descriptors	a small molecule
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

Discover Target: VDR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

Discover Target: PTH1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLB1 Tchem Beta-galactosidase (339 Activities)

Discover Target: GLB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCR6 Tchem C-C chemokine receptor type 6 (388 Activities)

Discover Target: CCR6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

Discover Target: SMAD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATXN2 Tbio Ataxin-2 (54410 Activities)

Discover Target: ATXN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3A Tclin Glycogen synthase kinase-3 (736 Activities)

Discover Target: GSK3A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

vpr Aberrant vpr protein (14595 Activities)

Discover Target: vpr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

37 results found

Lot Number	Certificate Type	Date	Item
C2626348	Certificate of Analysis	Mar 11, 2026	M100788
C2626349	Certificate of Analysis	Mar 11, 2026	M100788
C2626351	Certificate of Analysis	Mar 11, 2026	M100788
K2517633	Certificate of Analysis	Nov 04, 2025	M100788
K2517634	Certificate of Analysis	Nov 04, 2025	M100788
K2517635	Certificate of Analysis	Nov 04, 2025	M100788
K2517636	Certificate of Analysis	Nov 04, 2025	M100788
B2628243	Certificate of Analysis	Nov 04, 2025	M100788
A2203527	Certificate of Analysis	Oct 13, 2025	M100788
I2116298	Certificate of Analysis	Jun 09, 2025	M100788
F2527487	Certificate of Analysis	May 13, 2025	M100788
E2529169	Certificate of Analysis	May 13, 2025	M100788
F2527481	Certificate of Analysis	May 13, 2025	M100788
F2527482	Certificate of Analysis	May 13, 2025	M100788
F2527483	Certificate of Analysis	May 13, 2025	M100788
F2527484	Certificate of Analysis	May 13, 2025	M100788
F2527485	Certificate of Analysis	May 13, 2025	M100788
F2527486	Certificate of Analysis	May 13, 2025	M100788
G2417789	Certificate of Analysis	Jul 08, 2024	M100788
G2417788	Certificate of Analysis	Jul 08, 2024	M100788
G2417787	Certificate of Analysis	Jul 08, 2024	M100788
G2417786	Certificate of Analysis	Jul 08, 2024	M100788
G2417785	Certificate of Analysis	Jul 08, 2024	M100788
G2417784	Certificate of Analysis	Jul 08, 2024	M100788
B2506065	Certificate of Analysis	Jul 08, 2024	M100788
B2506117	Certificate of Analysis	Jul 08, 2024	M100788
B2526049	Certificate of Analysis	Jul 08, 2024	M100788
D2407385	Certificate of Analysis	Mar 15, 2024	M100788
D2407384	Certificate of Analysis	Mar 15, 2024	M100788
D2407383	Certificate of Analysis	Mar 15, 2024	M100788
L2312046	Certificate of Analysis	May 05, 2023	M100788
E2327322	Certificate of Analysis	May 05, 2023	M100788
E2327318	Certificate of Analysis	May 05, 2023	M100788
E2327314	Certificate of Analysis	May 05, 2023	M100788
E2327311	Certificate of Analysis	May 05, 2023	M100788
E2327054	Certificate of Analysis	May 05, 2023	M100788
B2317477	Certificate of Analysis	Dec 16, 2021	M100788

Chemical and Physical Properties

Solubility	Soluble in water.
Boil Point(°C)	125°C/10mmHg
Melt Point(°C)	93-95°C
Molecular Weight	97.070 g/mol
XLogP3	-0.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Exact Mass	97.0164 Da
Monoisotopic Mass	97.0164 Da
Topological Polar Surface Area	46.200 Å²
Heavy Atom Count	7
Formal Charge	0
Complexity	132.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Documents & Articles

Professional Guide to Streptavidin-Modified Proteins

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A Practical Guide to Small-Molecule Chemical Probes: Concept Clarification, Causal Validation, and Experimental Selection (with Product Navigation and Tables A–D)

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Chemical probe Small-Molecule Chemical Probes

Comparative Guide and Selection Framework for Common Fluorophores

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Quantum Dots Fluorescent dyes Flow Cytometry Fluorophore FRET Fluorescent protein Photobleaching Multicolor imaging

Pyrrole Research Reagent Selection Roadmap: Structure—Reactive Sites—Application Throughline and Reagent Classification Guide (Tables 1–4)

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

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Pyrrole five-membered aromatic

Designing Hydrogel Scaffolds as Programmable Cell Microenvironments: From Click-Chemistry Functionalization to 3D Cell Culture Experimental Design

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Hydrogel Three dimensional cell culture

Structural Design Logic of Common Resin Modification Technologies: Molecular Chain Structure, Functional Groups, Phase Structure, Crosslinked Networks, and Hybrid/Functional Design

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

resin Resin modification

Structure and Reactivity of Furan Compounds: How Substituents, Ring Fusion, and Degree of Hydrogenation Affect Reaction Sites and Application Directions

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Furan furfural Polycondensation

Why Proximity to Cysteine Does Not Necessarily Lead to Covalent Bond Formation: Warhead Reactivity, Reaction Geometry, and Target-Site Microenvironment

Categories: Technical Articles: Reagent Chemistry, Synthesis & Bioscience Guides

Tags:

Cysteine Covalent Inhibition

Citations of This Product

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Reviews

📚 Citations by Application

Organic synthesis — reaction medium4

Extraction & workup solvent1

Other applications4

Drug / compound screening4

Nanoparticle / material biocompatibility2

Cell viability1

Cell proliferation1

Cytotoxicity screening1

Controlled-release & nanoparticle carrier1

Cancer cell line characterization1

Topical & ophthalmic formulation1

Polymer synthesis & polymerization1

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Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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📚 Citations by Application

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