Masofaniten - ≥98% , CAS No.2416716-62-4

CAS: 2416716-62-4 Cat. No.: M647291 Formula: C₂₄H₂₄Cl₂N₄O₄S Molecular Weight: 535.44 PubChem CID: 146484310

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer

In Vitro

Masofaniten (compound A109, androgen-induced PSA-Luciferase assay) inhibits androgen binding to androgen receptor with an IC 50 of 535 nM. Masofaniten inhibits cell proliferation in LNCaP and LNCaP95 cells (IC 50 : 0.44 μM, 3.78 μM respectively). Masofaniten shows a metabolic stability in liver microsome with a t 1/2 of more than 120 min, and in hepatocytes with a t 1/2 of more than 360 min. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Masofaniten (compound A109) (60 mg/kg, p.o.) induces partial regressions of tumor growth in NCG mice bearing LNCaP tumors . Masofaniten (5 mg/kg, p.o., single dose, in male CD-1 mice) shows a t 1/2 of 8.1 h, C max of 2673.3 ng/mL, F (%) of 33.6 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: LNCaP Xenografts Model Dosage: 60 mg/kg Administration: Oral administration (p.o.) Result: Inhibited tumor growth no obvious drug related toxicity (bodyweight change).

Form:Solid

IC50& Target:Androgen receptor

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Masofaniten (Androgen receptor-IN-2) is a potent and orally active androgen receptor inhibitor. Masofaniten has antitumor activity against prostate cancer.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Isomeric SMILES: CC(C)(C1=CC=C(C=C1)OCC2=NC(=NC=C2)NS(=O)(=O)C)C3=CC(=C(C(=C3)Cl)OCCCl)C#N
• PubChem CID: 146484310
• Molecular Weight: 535.44

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (93.38 mM; Need ultrasonic and warming)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2416716-62-4, the molecular formula is C24H24Cl2N4O4S, and the molecular weight is 535.44 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.