Mefuparib hydrochloride - ≥98% , CAS No.1449746-00-2

CAS: 1449746-00-2 Cat. No.: M646255 Formula: C17H16ClFN2O2 Molecular Weight: 334.77 PubChem CID: 117734810
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Synonyms
Mefuparib (hydrochloride) | 82IYE3T3BE | CVL-218 | MPH | hydrochloride | 5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
★
Size
Germany (EU)
USA*
Price
Qty
1mg
M646255-1mg
Made to order · 8–12 wks
€99.70
5mg
M646255-5mg
—
2 In stock
€347.88
10mg
M646255-10mg
—
2 In stock
€608.20
25mg
M646255-25mg
—
1 In stock
€1,180.04
Enter a quantity for the sizes you want to add.
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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 14 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Mefuparib hydrochloride is a substrate-competitive and selective PARP1/2 inhibitor with IC50s of 3.2 nM and 1.9 nM, respectively. Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo.

Specifications

Synonyms
Mefuparib (hydrochloride) | 82IYE3T3BE | CVL-218 | MPH | hydrochloride | 5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide
Specifications & Purity
≥98%
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
Pubchem Sid
Canonical Smiles
CNCC1=CC=C(C=C1)C2=CC3=CC(=CC(=C3O2)C(=O)N)F.Cl
IUPAC Name
5-fluoro-2-[4-(methylaminomethyl)phenyl]-1-benzofuran-7-carboxamide;hydrochloride
InChIKey
GPFWTAVHQKERKY-UHFFFAOYSA-N
INCHI
1S/C17H15FN2O2.ClH/c1-20-9-10-2-4-11(5-3-10)15-7-12-6-13(18)8-14(17(19)21)16(12)22-15;/h2-8,20H,9H2,1H3,(H2,19,21);1H
Isomeric SMILES
CNCC1=CC=C(C=C1)C2=CC3=CC(=CC(=C3O2)C(=O)N)F.Cl
Alternate CAS
1449746-00-2
PubChem CID
117734810
MeSH Entry Terms
mefuparib hydrochloride;MPH1 cpd
Molecular Weight
334.77

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassPhenylpropanoids and polyketides
Class2-arylbenzofuran flavonoids
SubclassNot available
Intermediate Tree Nodes Not available
Direct Parent2-arylbenzofuran flavonoids
Alternative Parents 2-phenylbenzofurans  Phenylmethylamines  Benzylamines  Aralkylamines  Aryl fluorides  Heteroaromatic compounds  Furans  Oxacyclic compounds  Dialkylamines  Carboximidic acids  Organopnictogen compounds  Organooxygen compounds  Organofluorides  Hydrochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteropolycyclic compounds
Substituents 2-arylbenzofuran flavonoid - Phenylbenzofuran - 2-phenylbenzofuran - Benzofuran - Phenylmethylamine - Benzylamine - Aralkylamine - Benzenoid - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Heteroaromatic compound - Furan - Oxacycle - Organoheterocyclic compound - Secondary amine - Secondary aliphatic amine - Carboximidic acid derivative - Carboximidic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Hydrochloride - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Aromatic heteropolycyclic compound
DescriptionThis compound belongs to the class of organic compounds known as 2-arylbenzofuran flavonoids. These are phenylpropanoids containing the 2-phenylbenzofuran moiety.
External Descriptors Not available
3D Structure
Interactive Chemical Structure Model





Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot NumberCertificate TypeDateItem
E2431334Certificate of AnalysisMay 27, 2024 M646255
E2431335Certificate of AnalysisMay 27, 2024 M646255
E2431343Certificate of AnalysisMay 27, 2024 M646255
I2608061Certificate of AnalysisMay 27, 2024 M646255
Chemical and Physical Properties
SolubilityDMSO : 25 mg/mL (74.68 mM; Need ultrasonic)
SensitivityMoisture sensitive.
Molecular Weight334.800 g/mol
XLogP3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass334.088 Da
Monoisotopic Mass334.088 Da
Topological Polar Surface Area68.300 Ų
Heavy Atom Count23
Formal Charge0
Complexity398.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count2
Citations of This Product
Solution Calculators
Reviews

Customer Reviews

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