Methyclothiazide - Moligand™, 10mM in DMSO , Thiazide-sensitive sodium-chloride cotransporter inhibitor, CAS No.135-07-9, Thiazide-sensitive sodium-chloride cotransporter inhibitor

CAS: 135-07-9 Cat. No.: M408281 Formula: C₉H₁₁Cl₂N₃O₄S₂ Molecular Weight: 360.24

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
In vitro

Methyclothiazide (0.1 mM) reduces Ca²⁺ contractures with maximal inhibition of 90.4% in SHR aortic rings with endothelium. The inhibitory effect of Methyclothiazide (0.1 mM) on Ca²⁺ contracture is significantly but not totally abolished by the NO synthase inhibitor in SHR aortic rings with functional endothelium. Methyclothiazide (0.1 mM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from spontaneously hypertensive rats (SHR) rather than normotensive Wistar Kyoto rats (WKY), and the maximal vasoconstrictive effect of NE and AVP is decreased by 59% and 32.3%, respectively. Methyclothiazide (3.5 mM) inhibits renin release in rat kidney slices.

In vivo

Methyclothiazide (0.1 g/L for the first 5 weeks and 0.2 g/L for the second 2 weeks, drinking water) attenuates development of hypertension in salt-sensitive (DS) rats, but does not affect blood pressure in salt-resistant (DR) ones. The methyclothiazide-treated DOCA-salt rats weigh less than controls or the nonsupplemented DOCA-salt rats at weeks 3 and 4. Methyclothiazide added to the drinking water of DOCA-salt rats attenuates the elevation of blood pressure.
Cell Data

cell lines：PC12 cell

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Methyclothiazide is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Thiazide-sensitive sodium-chloride cotransporter inhibitor

Product Properties

ALogP

1.4

Names and Identifiers

Isomeric SMILES

CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CCl

Molecular Weight

360.24

Reaxy-Rn

765361

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=765361&ln=