Mildronate - ≥98% , CAS No.76144-81-5

CAS: 76144-81-5 Cat. No.: M189201 Molecular Weight: 146.19 EC Number: 682-135-0

GRADE & PURITY ≥98%

Synonyms

3-[(trimethylazaniumyl)amino]propanoate | MELDONIUM [MART.] | Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, hydroxide, inner salt | Kvaterin | Melatonin (JAN) | 73H7UDN6EC | AKOS015906002 | BCP04503 | Meldonium dihydrate, >=98% (HPLC), powder | Mildro

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

3-[(trimethylazaniumyl)amino]propanoate | MELDONIUM [MART.] | Hydrazinium, 2-(2-carboxyethyl)-1, 1, 1-trimethyl-, hydroxide, inner salt | Kvaterin | Melatonin (JAN) | 73H7UDN6EC | AKOS015906002 | BCP04503 | Meldonium dihydrate, >=98% (HPLC), powder | Mildro

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine.Fatty acid oxidation inhibitor. GBB hydrolase-dependent L-carnitine biosynthesis inhibitor. Competitive renal carnitine reabsorption inhibitor. γ-bu

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504756952
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756952
• Canonical Smiles: C[N+](C)(C)NCCC(=O)[O-]
• IUPAC Name: 3-[(trimethylazaniumyl)amino]propanoate
• InChIKey: PVBQYTCFVWZSJK-UHFFFAOYSA-N
• INCHI: 1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3
• Isomeric SMILES: C[N+](C)(C)NCCC(=O)[O-]
• Molecular Weight: 146.19
• Reaxy-Rn: 3938272
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3938272&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Beta amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Beta amino acids and derivatives
• Alternative Parents: Carboxylic acid salts Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organonitrogen compounds Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Beta amino acid or derivatives - Carboxylic acid salt - Monocarboxylic acid or derivatives - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as beta amino acids and derivatives. These are amino acids having a (-NH2) group attached to the beta carbon atom.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

BBOX1 Tchem Gamma-butyrobetaine dioxygenase (162 Activities)

Discover Target: BBOX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Moisture sensitive.
• Molecular Weight: 146.190 g/mol
• XLogP3: -2.100
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 146.106 Da
• Monoisotopic Mass: 146.106 Da
• Topological Polar Surface Area: 52.200 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 112.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Yanyu Zhang, Chenhao Hu, Jingchuan Liu, Sirong Jiang, Qian Liu, Xin Zhou, Yiling Liu, Feibiao Song, Jian Luo.  (2026)  Tissue-specific metabolic remodeling to opposite fatty acid oxidation regulation in golden pompano identified by dual-tissue multi-omics.  AQUACULTURE,      [PMID:] [10.1016/j.aquaculture.2026.744174]