Mito-LND - ≥97% , CAS No.2361564-49-8

CAS: 2361564-49-8 Cat. No.: M647144 Formula: C₄₃H₄₅BrCl₂N₃OP Molecular Weight: 801.62 PubChem CID: 155977659

GRADE & PURITY ≥97%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species , and induces autophagic cell death in lung cancer cells.

In Vitro

Mito-LND blocks lung cancer growth, migration, and invasion. Mito-LND inhibits cell growth of H2030BrM3 and A549 cells with IC 50 values of 0.74 µM and 0.69 µM, respectively. Mito-LND inhibits mitochondrial complex I and II activities with IC 50 values of 1.2 µM and 2.4 µM, respectively in H2030BrM3 cells. Mito-LND (1 µM) increases ROS generation in H2030BrM3 lung cancer cells. Mito-LND potently induces mitochondrial ROS generation in H2030BrM3 lung cancer cells. Mito-LND (2 µM) decreases the levels of phosphorylated AKT. Mito-LND also decreases the phosphorylation of P70S6K and other energy-sensing proteins in both the parental and metastatic lung cancer cell lines, indicating that Mito-LND specifically downregulates mTOR signaling. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mito-LND (7.5 µmol/kg; oral gavage; 5 days per week; for 3 consecutive weeks) treatment markedly enhanced potency against both lung cancer progression and metastasis . Mito-LND also decreases the rate of growth of A549 tumor xenografts . Mito-LND treatment shows a marked decrease in lung cancer brain metastasis in NOD/SCID mice bearing H2030BrM3 cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Athymic nude mice (5 weeks) injected with H2030BrM3 cells Dosage: 7.5 µmol/kg Administration: Oral gavage; 5 days per week; for 3 consecutive weeks Result: Significantly decreased tumor progression.

Form:Solid

Specifications

Specifications & Purity

≥97%

Biochemical and Physiological Mechanisms

Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS) . Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species , and induces autophagic cell dea

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥97%

Names and Identifiers

• Canonical Smiles: C1=CC=C(C=C1)[P+](CCCCCCCCCCNC(=O)C2=NN(C3=CC=CC=C32)CC4=C(C=C(C=C4)Cl)Cl)(C5=CC=CC=C5)C6=CC=CC=C6.[Br-]
• IUPAC Name: 10-[[1-[(2,4-dichlorophenyl)methyl]indazole-3-carbonyl]amino]decyl-triphenylphosphanium;bromide
• InChIKey: XRSSFQSESARZNG-UHFFFAOYSA-N
• INCHI: 1S/C43H44Cl2N3OP.BrH/c44-35-29-28-34(40(45)32-35)33-48-41-27-17-16-26-39(41)42(47-48)43(49)46-30-18-5-3-1-2-4-6-19-31-50(36-20-10-7-11-21-36,37-22-12-8-13-23-37)38-24-14-9-15-25-38;/h7-17,20-29,32H,1-6,18-19,30-31,33H2;1H
• Isomeric SMILES: C1=CC=C(C=C1)[P+](CCCCCCCCCCNC(=O)C2=NN(C3=CC=CC=C32)CC4=C(C=C(C=C4)Cl)Cl)(C5=CC=CC=C5)C6=CC=CC=C6.[Br-]
• PubChem CID: 155977659
• Molecular Weight: 801.62

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (62.37 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥97% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2361564-49-8, the molecular formula is C43H45BrCl2N3OP, and the molecular weight is 801.62 g/mol. InChIKey XRSSFQSESARZNG-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.