MLN3126 - ≥98% , CAS No.628300-71-0

CAS: 628300-71-0 Cat. No.: M646769 Formula: C₂₁H₁₉ClN₂O₅S Molecular Weight: 446.90

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC 50 value of 6.3 nM for calcium influx.

In Vitro

MLN3126 inhibits CCL25-induced calcium mobilization with an IC 50 value of 6.3 nM in CCR9 expressing cells. MLN3126 inhibits the binding of biotinylated CCL25 to CCR9 with an IC 50 of 14.2 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Invasion AssayCell Line: Mouse thymocytes Concentration: 0.01, 0.03, 0.1, 0.3, 1, 3 μM Incubation Time: 90 min Result: Inhibited CCL25-induced chemotaxis of mouse thymocytes.

In Vivo

MLN3126 (2.5% w/w; p.o.) decreases colonic level of IFN-γ, largely produced by T cells . MLN3126 (0.05, 0.25 and 1% (w/w); p.o.) has the potential activity for alleviating inflammatory bowel disease (IBD) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Activated T cell transferred colitis mouse model Dosage: 0.05, 0.25 and 1% (w/w) (around 4 g/day) Administration: Oral gavage; 21 days Result: Blocked CCR9/CCL25 interaction by inhibiting migration of T cells to the colon and resulted in the amelioration of colitis.

Form:Solid

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

MLN3126 is an orally active and potent CCR9 antagonist. MLN3126 inhibits CCL25-induced calcium mobilization and chemotaxis of mouse primary thymocytes, wiht an IC 50 value of 6.3 nM for calcium influx.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ANTAGONIST

Purity

≥98%

Names and Identifiers

• Molecular Weight: 446.90

Chemical and Physical Properties

• Solubility: DMSO : 25 mg/mL (55.94 mM; ultrasonic and warming and heat to 60°C)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 628300-71-0, the molecular formula is C21H19ClN2O5S, and the molecular weight is 446.90 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.