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· · COA & SDS available for every product · Same-day shipping on in-stock items MN 64 - 10mM in DMSO , CAS No.92831-11-3
GRADE & PURITY 10mM in DMSO
Synonyms
2-[4-(propan-2-yl)phenyl]-4H-chromen-4-one|2-(4-Isopropylpheny)-4H-chroMen-4-one|MN64|mn-64|Bio2B2|MN 64|2-(4-isopropylphenyl)-4H-chromen-4-one|2-(4-propan-2-ylphenyl)chromen-4-one|4'-Isopropylflavone
Shipped In
Dry ice packs + Cold packs
Overview Information
MN 64 MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.
Targets
TNKS1 ; TNKS2 6 nM; 72 nM
In vitro
MN-64 inhibits WNT/β-catenin signaling-dependent Super-TopFlash (STF) luciferase activity.
Specifications Synonyms
2-[4-(propan-2-yl)phenyl]-4H-chromen-4-one | 2-(4-Isopropylpheny)-4H-chroMen-4-one | MN64 | mn-64 | Bio2B2 | MN 64 | 2-(4-isopropylphenyl)-4H-chromen-4-one | 2-(4-propan-2-ylphenyl)chromen-4-one | 4'-Isopropylflavone
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively.
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Product Properties Names and Identifiers Canonical Smiles
CC(C)C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
IUPAC Name
2-(4-propan-2-ylphenyl)chromen-4-one
InChIKey
PYTOHIUBXSJKQH-UHFFFAOYSA-N
INCHI
1S/C18H16O2/c1-12(2)13-7-9-14(10-8-13)18-11-16(19)15-5-3-4-6-17(15)20-18/h3-12H,1-2H3
Isomeric SMILES
CC(C)C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
Reaxys-RN_link_address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5269408&ln=
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Phenylpropanoids and polyketides Class Flavonoids Subclass Flavones Intermediate Tree Nodes Not available Direct Parent Flavones Alternative Parents Chromones Bicyclic monoterpenoids Aromatic monoterpenoids Phenylpropanes Cumenes Pyranones and derivatives Heteroaromatic compounds Oxacyclic compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Flavone - Chromone - P-cymene - Aromatic monoterpenoid - Benzopyran - Bicyclic monoterpenoid - Monoterpenoid - 1-benzopyran - Cumene - Phenylpropane - Pyranone - Benzenoid - Monocyclic benzene moiety - Pyran - Heteroaromatic compound - Organoheterocyclic compound - Oxacycle - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as flavones. These are flavonoids with a structure based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates (CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties DMSO(mg / mL) Max Solubility 53 DMSO(mM) Max Solubility 200.514527845036 Water(mg / mL) Max Solubility ＜1 Molecular Weight 264.300 g/mol XLogP3 4.700 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2 Rotatable Bond Count 2 Exact Mass 264.115 Da Monoisotopic Mass 264.115 Da Topological Polar Surface Area 26.300 Ų Heavy Atom Count 20 Formal Charge 0 Complexity 388.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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