MRT68921 HCl - 10mM in DMSO , CAS No.1190379-70-4(freebase)

CAS: 1190379-70-4(freebase) Cat. No.: M420842 Formula: C₂₅H₃₄N₆O·xHCl Molecular Weight: 434.6（freebase）

GRADE & PURITY 10mM in DMSO

Synonyms

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

Targets

ULK2 (Cell-free assay); ULK1 (Cell-free assay) 1.1 nM; 2.9 nM

In vitro

MRT68921 specifically disrupts autophagosome maturation and thus blocks autophagic flux through ULK1 inhibition.

Cell Research(from reference)

Cell lines：MEFs and 293T cells 

Concentrations：1 μM 

Incubation Time：1 h 

Specifications

Synonyms

N-​[3-​[[5-​cyclopropyl-​2-​[(1,​2,​3,​4-​tetrahydro-​2-​methyl-​6-​isoquinolinyl)​amino]​-​4-​pyrimidinyl]​amino]​propyl]​-Cyclobutanecarboxamide hydrochloride

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Product Properties

ALogP

4.644

hba_count

3

HBD Count

3

Rotatable Bond

9

Names and Identifiers

Alternate CAS

2080306-21-2

Molecular Weight

434.6（freebase）

Reaxy-Rn

19608518

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19608518&ln=

Chemical and Physical Properties

• DMSO(mg / mL) Max Solubility: 10
• DMSO(mM) Max Solubility: 23.010723
• Water(mg / mL) Max Solubility: ＜1

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1190379-70-4(freebase), the molecular formula is C25H34N6O·xHCl, and the molecular weight is 434.6（freebase） g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.