MSA-2 dimer - ≥99% , CAS No.2377881-92-8

CAS: 2377881-92-8 Cat. No.: M650506 Formula: C₂₉H₂₈O₈S₂ Molecular Weight: 568.66

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist ( K d =145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide

In Vivo

MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival . MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression . MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors . MSA-2 dimer (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues . MSA-2 dimer (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 dimer (10 μM and 33 μM; macrophages) induces IFN-β . MSA-2 dimer also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: B16F10 tumor-bearing mice Dosage: 60 mg/kg Administration: P.o.; 50 days Result: Inhibited tumor growth and prolonged overall survival. Animal Model: C57BL6 mice Dosage: 40 mg/kg Administration: S.c.; 25 days Result: Induced complete tumor regression. Animal Model: C57BL6 mice Dosage: 60 mg/kg Administration: P.o.; 4 hours Result: Increased proinflammatory cytokine (IFN-β) level in tumors. Animal Model: C57BL6 mice Dosage: 50 mg/kg Administration: S.c.; 4 hours Result: MSA-2 concentrations were observed in tumors than in plasma or other nontumor tissues.

Form:Solid

IC50& Target:Kd: 145 μM (STING)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist ( K d =145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide.

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥99%

Names and Identifiers

• Molecular Weight: 568.66

Chemical and Physical Properties

• Solubility: DMSO : 70 mg/mL (123.10 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2377881-92-8, the molecular formula is C29H28O8S2, and the molecular weight is 568.66 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.