N-Acetylpuromycin - ≥98%(HPLC) , CAS No.22852-13-7

CAS: 22852-13-7 Cat. No.: N288941 Formula: C₂₄H₃₁N₇O₆ Molecular Weight: 513.55 PubChem CID: 46173769

GRADE & PURITY ≥98%(HPLC)

Synonyms

3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Downregulates SnoN and Ski protein expression; promotes TGF-βsignaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

Canonical Smiles

CC(=O)NC(CC1=CC=C(C=C1)OC)C(=O)NC2C(OC(C2O)N3C=NC4=C3N=CN=C4N(C)C)CO

IUPAC Name

(2S)-2-acetamido-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide

InChIKey

LADKVYSQIGJMFP-IYRMOJGWSA-N

INCHI

1S/C24H31N7O6/c1-13(33)28-16(9-14-5-7-15(36-4)8-6-14)23(35)29-18-17(10-32)37-24(20(18)34)31-12-27-19-21(30(2)3)25-11-26-22(19)31/h5-8,11-12,16-18,20,24,32,34H,9-10H2,1-4H3,(H,28,33)(H,29,35)/t16-,17+,18+,20+,24+/m0/s1

Isomeric SMILES

CC(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H]2[C@H](O[C@H]([C@@H]2O)N3C=NC4=C3N=CN=C4N(C)C)CO

PubChem CID

46173769

Molecular Weight

513.55

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Class Purine nucleosides
      • Subclass Purine 3'-deoxyribonucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Class: Purine nucleosides
• Subclass: Purine 3'-deoxyribonucleosides
• Intermediate Tree Nodes: Not available
• Direct Parent: Purine 3'-deoxyribonucleosides
• Alternative Parents: Phenylalanine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid amides Glycosylamines 6-alkylaminopurines Pentoses Amphetamines and derivatives Methoxybenzenes Anisoles Dialkylarylamines Phenoxy compounds Alkyl aryl ethers Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Fatty amides Oxolanes Acetamides Heteroaromatic compounds Secondary alcohols Secondary carboxylic acid amides Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Organic oxides Carbonyl compounds Primary alcohols
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Purine 3'-deoxyribonucleoside - Phenylalanine or derivatives - N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - 6-alkylaminopurine - N-glycosyl compound - Glycosyl compound - 6-aminopurine - Pentose monosaccharide - N-substituted-alpha-amino acid - Alpha-amino acid or derivatives - Amphetamine or derivatives - Imidazopyrimidine - Purine - Dialkylarylamine - Phenol ether - Anisole - Methoxybenzene - Phenoxy compound - Alkyl aryl ether - Aminopyrimidine - Monocyclic benzene moiety - Fatty amide - Fatty acyl - Imidolactam - Monosaccharide - Benzenoid - N-substituted imidazole - Pyrimidine - Heteroaromatic compound - Imidazole - Oxolane - Azole - Acetamide - Amino acid or derivatives - Secondary alcohol - Secondary carboxylic acid amide - Tertiary amine - Carboxamide group - Organoheterocyclic compound - Ether - Carboxylic acid derivative - Oxacycle - Azacycle - Amine - Organic nitrogen compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Alcohol - Organic oxygen compound - Organic oxide - Primary alcohol - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as purine 3'-deoxyribonucleosides. These are compounds consisting of a purine linked to a ribose which lacks a hydroxyl group at position 3.
• External Descriptors: puromycins

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PC-3 (62116 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 51.35, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 51.35, Max Conc. mM: 100
• Molecular Weight: 513.500 g/mol
• XLogP3: 0.300
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 9
• Exact Mass: 513.234 Da
• Monoisotopic Mass: 513.234 Da
• Topological Polar Surface Area: 164.000 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 783.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Frequently Asked Questions

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 22852-13-7, the molecular formula is C24H31N7O6, and the molecular weight is 513.55 g/mol. InChIKey LADKVYSQIGJMFP-IYRMOJGWSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.