Nampt activator-2 - ≥98% , CAS No.2237268-90-3

CAS: 2237268-90-3 Cat. No.: N647016 Formula: C₁₇H₁₅ClN₄O₃S Molecular Weight: 390.84

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC 50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM).

In Vitro

Nampt activator-2 (compound 34) (10 μM, 4 h) results in a marked increase of both NMN and NAD in A549 lung epithelial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt activator-2 (compound 34) (1 mg/kg iv and 10 mg/kg po, once) shows low plasma clearance, good exposure and excellent oral bioavailability (%F = 80) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mouse Dosage: 1 mg/kg iv and 10 mg/kg po Administration: IV, PO; once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of Nampt activator-2 in mouse . IV (1 mg/kg) PO (10 mg/kg) C max (ng/mL) 9550 AUC 0-24 (ng/mL∗h) 54463 t 1/2 (h) 3.2 CL (mL/min/kg) 3 Vd (L/kg) 0.61 F (%) 80

Form:Solid

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Nampt activator-2 (compound 34) is a potent NAMPT activator, with EC 50 of 0.023 μM. Nampt activator-2 shows moderate activity against CYP2C9 (0.060 μM), 2D6 (0.41 μM) and 2C19 (0.59 μM).

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥98%

Names and Identifiers

Molecular Weight

390.84

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (639.65 mM; Need ultrasonic)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2237268-90-3, the molecular formula is C17H15ClN4O3S, and the molecular weight is 390.84 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.