Nimesulide - Moligand™, 10mM in DMSO , Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2, CAS No.51803-78-2, Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2

CAS: 51803-78-2 Cat. No.: N407977 Formula: C₁₃H₁₂N₂O₅S Molecular Weight: 308.31 EC Number: 257-431-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

N-​(4-​nitro-​2-​phenoxyphenyl)​-methanesulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Nimesulide is a relativelyCOX-2selective inhibitor withIC50of 26 μM.
In vitro

In vivo

Cell Data

cell lines：HepG2 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

N-​(4-​nitro-​2-​phenoxyphenyl)​-methanesulfonamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2

Names and Identifiers

Isomeric SMILES

CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2

WGK Germany

3

RTECS

PB0970000

Molecular Weight

308.31

Reaxy-Rn

2421175

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2421175&ln=

Associated Targets(Human)

SLC6A19 Tchem Sodium-dependent neutral amino acid transporter B(0)AT1 (1 Activities)

Discover Target: SLC6A19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (8 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 66 mg/mL (198.11 mM); Ethanol: -1 mg/mL
• Melt Point(°C): 150 °C