Nortriptyline Hydrochloride - ≥98%(HPLC) , Norepinephrine transporter inhibitor, CAS No.894-71-3, Norepinephrine transporter inhibitor

Name: Nortriptyline Hydrochloride - ≥98%(HPLC) , Norepinephrine transporter inhibitor, CAS No.894-71-3, Norepinephrine transporter inhibitor
SKU: N136755
Availability: InStock

CAS: 894-71-3 Cat. No.: N136755 Formula: C₁₉H₂₁N · HCl Molecular Weight: 299.84 EC Number: 212-973-0

2 Citations COA

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Nortriptyline Hydrochloride - ≥98%(HPLC) CAS No(894-71-3) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%(HPLC)

Synonyms

Altilev | Nortriptyline (hydrochloride) | Tox21_110048 | Nortriptyline hydrochloride (USAN:USP:JAN) | NSC78248 | NSC-78248 | D00816 | Nortriptyline for system suitability | REGID_for_CID_441358 | Tox21_500868 | HY-B1417 | MLS001077267 | Norzepine | 3-(10,

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product Solution Calculators Reviews

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Norepinephrine transporter inhibitor

Purity

≥98%(HPLC)

Names and Identifiers

Pubchem Sid

504758761

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504758761

Canonical Smiles

CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

IUPAC Name

N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine;hydrochloride

InChIKey

SHAYBENGXDALFF-UHFFFAOYSA-N

INCHI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H

Isomeric SMILES

CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

WGK Germany

RTECS

HP0175000

Molecular Weight

299.84

Reaxy-Rn

4163872

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4163872&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Dibenzocycloheptenes

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Dibenzocycloheptenes
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Dibenzocycloheptenes
Alternative Parents	Dialkylamines Organopnictogen compounds Organic chloride salts Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Dibenzocycloheptene - Secondary amine - Secondary aliphatic amine - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organic chloride salt - Organic salt - Organonitrogen compound - Amine - Aromatic homopolycyclic compound
Description	This compound belongs to the class of organic compounds known as dibenzocycloheptenes. These are compounds containing a dibenzocycloheptene moiety, which consists of two benzene rings connected by a cycloheptene ring.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

Discover Target: SLC6A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
F2623328	Certificate of Analysis	Jun 11, 2026	N136755
F2623329	Certificate of Analysis	Jun 11, 2026	N136755
F2623335	Certificate of Analysis	Jun 11, 2026	N136755
K2103330	Certificate of Analysis	May 09, 2025	N136755
K2103332	Certificate of Analysis	Aug 04, 2023	N136755

Solubility	ethanol: 100 mg/mL H2O: soluble
Sensitivity	Sensitive to light
Melt Point(°C)	218 °C
Molecular Weight	299.800 g/mol
XLogP3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Exact Mass	299.144 Da
Monoisotopic Mass	299.144 Da
Topological Polar Surface Area	12.000 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	307.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Nortriptyline Hydrochloride - ≥98%(HPLC) , Norepinephrine transporter inhibitor, CAS No.894-71-3, Norepinephrine transporter inhibitor

Storage & shipping

Quality documents

Literature proof

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

📚 Citations by Application

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