NPC-349, Antagonist of B 2 receptor, CAS No.103412-42-6, Antagonist of B 2 receptor

CAS: 103412-42-6 Cat. No.: rp174656 PubChem CID: 123973
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
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Size
Germany (EU)
USA*
Price
Qty
500μg
rp174656-500μg
Made to order · 8–12 wks
€2,082.49
1mg
rp174656-1mg
Made to order · 8–12 wks
€3,470.87
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Why this grade

Moligand™ Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Product Name
NPC-349, Antagonist of B 2 receptor, CAS No.103412-42-6
Synonyms
Arg-3-hyp-5,8-thi-7-phe-bradykinin | Bradykinin, D-arg(0)-hyp(3)-D-phe(7)-thi(5,8) | NPC-349 | B 6572 | B-4162 | (Arg(0)-hyp(3)-thi(5)-phe(7)-thi(8))bradykinin | Bradykinin, arg-hyp(3)-gly-(2-thi-ala)(5)-phe(7)-(2-thi-ala)(8)- | Arg-3-hyp-5-(2-thi-ala)-7-
Grade
Moligand™
Specifications & Purity
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of B 2 receptor
CAS
103412-42-6
Molecule Type
Peptide
Storage and Shipping
Storage
Room temperature

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Peptides
Direct ParentOligopeptides
Alternative Parents Phenylalanine and derivatives  Proline and derivatives  N-acyl-L-alpha-amino acids  Serine and derivatives  Alpha amino acid amides  Amphetamines and derivatives  Pyrrolidinecarboxamides  N-acylpyrrolidines  Gamma-keto acids and derivatives  Beta-keto acids and derivatives  Aralkylamines  N-substituted carboxylic acid imides  N-acyl amines  Beta-hydroxy ketones  Thiophenes  Tertiary carboxylic acid amides  Heteroaromatic compounds  Dicarboximides  Secondary carboxylic acid amides  Secondary alcohols  Guanidines  Amino acids  1,2-aminoalcohols  Propargyl-type 1,3-dipolar organic compounds  Monocarboxylic acids and derivatives  Dialkylamines  Carboxylic acids  Carboximidamides  Azacyclic compounds  Primary alcohols  Organopnictogen compounds  Organic oxides  Monoalkylamines  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Alpha-oligopeptide - Phenylalanine or derivatives - Proline or derivatives - N-acyl-l-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-alpha-amino acid - Serine or derivatives - Alpha-amino acid amide - Amphetamine or derivatives - Alpha-amino acid or derivatives - N-substituted-alpha-amino acid - Pyrrolidine-2-carboxamide - Pyrrolidine carboxylic acid or derivatives - N-acylpyrrolidine - Gamma-keto acid - Aralkylamine - Beta-keto acid - Fatty acyl - Benzenoid - Carboxylic acid imide, n-substituted - N-acyl-amine - Keto acid - Fatty amide - Beta-hydroxy ketone - Monocyclic benzene moiety - Heteroaromatic compound - Thiophene - Tertiary carboxylic acid amide - Pyrrolidine - Dicarboximide - Carboxylic acid imide - Amino acid - Secondary carboxylic acid amide - Secondary alcohol - Ketone - Guanidine - Carboxamide group - Amino acid or derivatives - 1,2-aminoalcohol - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Carboximidamide - Secondary amine - Monocarboxylic acid or derivatives - Secondary aliphatic amine - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Carbonyl group - Amine - Alcohol - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as oligopeptides. These are organic compounds containing a sequence of between three and ten alpha-amino acids joined by peptide bonds.
External Descriptors Not available
Associated Targets(Human)
BDKRB2 Tclin B2 bradykinin receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Genetic information
Alternate NamesArg-3-hyp-5,8-thi-7-phe-bradykinin | Bradykinin, D-arg(0)-hyp(3)-D-phe(7)-thi(5,8) | NPC-349 | B 6572 | B-4162 | (Arg(0)-hyp(3)-thi(5)-phe(7)-thi(8))bradykinin | Bradykinin, arg-hyp(3)-gly-(2-thi-ala)(5)-phe(7)-(2-thi-ala)(8)- | Arg-3-hyp-5-(2-thi-ala)-7-
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more
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Frequently Asked Questions

What is Moligand??
Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.
How should this product be stored?
Store at room temperature.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is 103412-42-6. InChIKey MHBUKMPYIGAURU-WIDHDRDXSA-N.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

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