NRD167 , CAS No.2166487-23-4

CAS: 2166487-23-4 Cat. No.: N419999

Synonyms

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Sequence:Z-Lys(thiourea-beta-Ala-OEt)-Trp-Isopropylamine

Specifications

Synonyms

Ethyl-(5S,8S)-5-((1H-indol-3-yl)methyl)-8-(((benzyloxy)carbonyl)amino)-2-methyl-4,7-dioxo-14-thioxo-3,6,13,15-tetraazaoctadecan-18-oate | Et-29

Biochemical and Physiological Mechanisms

RD167 is the ethylester prodrug of a potent and selective sirtuin 5 (SIRT5) inhibitor (IC50 = 370 nM; <10% inhibition of SIRT1/2/3/6 at 10 μM). NRD167 exhibits anti-proliferation (IC50 = 5-8 μM) and apoptosis-induction efficacy (>80% at 5-8 μM) against SI

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Chemical and Physical Properties

• Solubility: DMSO: 2 mg/mL, clear
• Sensitivity: Light sensitive

References

1. Zekun Liu, Jie Hu, Yinan Lin, Chuang Ge, Yuru Shao, Mengmeng Bao, Mengjie Liu, Shilin Jia, Yating Li, Xiaozhi Xu, Ruiyan Li, Qizhou Jiang, Fangrong Yan, Fei Xiao, Junmei Ye.  (2025)  SIRT5 Facilitates Liver Steatosis Progression via Promoting SDH Desuccinylation During High-Fat Diet Feeding.  LIVER INTERNATIONAL,  45  (12): (e70433).  [PMID:41221659] [10.1111/liv.70433]