NS 383 - Moligand™ , Channel blocker of ASIC1;Channel blocker of ASIC3, CAS No.309711-59-9, Channel blocker of ASIC1;Channel blocker of ASIC3

CAS: 309711-59-9 Cat. No.: N288698 Formula: C₁₉H₁₉N₃O₂ Molecular Weight: 321.37 PubChem CID: 135418391

GRADE & PURITY Moligand™

Synonyms

8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

8-Ethyl-6,7,8,9-tetrahydro-5-phenyl-1H-pyrrolo[3,2-h]isoquinoline-2,3-dione-3-oxime

Specifications & Purity

Moligand™

Biochemical and Physiological Mechanisms

ASIC blocker (IC50values are 0.44, 2.1 μM and no effect at rat ASIC1a, ASIC3 and ASIC2a, respectively: IC50value = 0.12 μM at human ASIC1a with no effect at ASIC2a or ASIC3). Inhibition was also observed at heteromeric ASIC channels (IC50values are 0.79,

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of ASIC1;Channel blocker of ASIC3

Names and Identifiers

• Canonical Smiles: CCN1CCC2=C(C=C3C(=C2C1)NC(=C3N=O)O)C4=CC=CC=C4
• IUPAC Name: 8-ethyl-3-nitroso-5-phenyl-1,6,7,9-tetrahydropyrrolo[3,2-h]isoquinolin-2-ol
• InChIKey: OZVZKENYKWSYBC-UHFFFAOYSA-N
• INCHI: 1S/C19H19N3O2/c1-2-22-9-8-13-14(12-6-4-3-5-7-12)10-15-17(16(13)11-22)20-19(23)18(15)21-24/h3-7,10,20,23H,2,8-9,11H2,1H3
• PubChem CID: 135418391
• Molecular Weight: 321.37

Associated Targets(Human)

ASIC3 Tchem Acid-sensing ion channel 3 (0 Activities)

Discover Target: ASIC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ASIC1 Tchem Acid-sensing ion channel 1 (0 Activities)

Discover Target: ASIC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 1.61, Max Conc. mM: 5

Frequently Asked Questions

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 309711-59-9, the molecular formula is C??H??N?O?, and the molecular weight is 321.37 g/mol. InChIKey OZVZKENYKWSYBC-UHFFFAOYSA-N.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.