NY2267 - 10mM in DMSO , CAS No.886053-73-2

CAS: 886053-73-2 Cat. No.: N656758 Formula: C₃₈H₄₃N₃O₆ Molecular Weight: 637.76 PubChem CID: 12000419

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

NY2267 is a disruptor of Myc-Max interaction , with an IC 50 of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation.

In Vitro

NY2267 strongly inhibits oncogenic transformation induced by Myc. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

NY2267 is a disruptor of Myc-Max interaction , with an IC 50 of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

PubChem CID

12000419

Molecular Weight

637.76

Application Protocols

The following are general, literature-based protocols for handling small-molecule test articles in biochemical or cell-based assays. They are not item-specific validated methods for NY2267.

Stock solution preparation

• Calculate mass using the exact molecular weight from the CoA. Prepare a concentrated stock in anhydrous DMSO (e.g., 10–50 mM depending on solubility).
• Mix thoroughly (vortex), inspect for clarity, and if needed, gently warm or briefly sonicate. Avoid prolonged heating.
• Aliquot into low-adsorption tubes to minimize freeze–thaw.

Serial dilutions and dosing

• Prepare serial dilutions in DMSO (e.g., 3-fold or 10-fold) and back-dilute into assay buffer to achieve the final concentration range. Maintain constant final DMSO (commonly ≤0.1–1% v/v).
• Include vehicle controls and, if available, positive/negative control ligands.

Assay interference controls

• Test for compound fluorescence/absorbance overlap with assay readouts; adjust wavelengths or use orthogonal formats if needed.
• Mitigate aggregation with a small amount of nonionic detergent if compatible.

Analytical confirmation

• Verify dose solutions by UPLC–MS for identity and absence of degradation/precipitation, especially at the highest concentrations.

Documentation

• Record lot number, preparation date, solvent, and concentration on aliquot labels and in ELN/LIMS.

Item-specific validated applications for NY2267: Not specified for this item; refer to CoA/Spec Sheet.

Biological Roles

Specific biological targets, pathways, and roles for NY2267 are not provided in the product data.

Item-specific biological information

• Target/mechanism: Not specified for this item; refer to CoA/Spec Sheet and peer-reviewed literature associated with CAS 886053-73-2 or CID 12000419.
• Bioactivity profile: Not specified for this item; refer to CoA/Spec Sheet.

General considerations for small-molecule research tools

• Phenotypic vs. target-based: In phenotypic assays, use secondary target-deconvolution methods (e.g., chemoproteomics, CRISPR knockouts, thermal shift assays) to identify putative targets. In target-based assays, confirm binding/functional modulation by orthogonal readouts.
• Selectivity: Construct panel assays across related enzymes/receptors/ion channels to quantify off-target activity and define selectivity windows.
• ADME proxies: If needed, assess solubility, permeability (PAMPA/MDCK), microsomal stability, and protein binding to contextualize cellular potency and apparent efficacy.
• Aggregation/fluorescence: Screen for intrinsic fluorescence or redox activity that may confound optical or coupled assays.

Usage notes

• Maintain consistent vehicle concentration across wells/conditions.
• Confirm compound identity and purity periodically via LC–MS, especially after extended storage.

All biological information above is general guidance (literature/practice). No clinical or therapeutic claims are made; this material is for research use only.

Buffer Applications

This product is a small-molecule research compound and not a buffering agent.

• Conventional buffer roles (pH control, ionic strength modulation) do not apply directly.
• For assay use, prepare buffers appropriate to your biological system (e.g., PBS, HEPES, Tris, MES) and introduce the compound via concentrated DMSO or other suitable stock.

Practical notes (general)

• Keep final DMSO concentration constant across all assay wells (commonly ≤0.1–1% v/v) to avoid solvent-driven artifacts.
• If precipitation is observed on dilution, adjust the dilution sequence (add compound last), include modest surfactant if assay-compatible, or consider cyclodextrin-assisted solubilization.

Item-specific buffer compatibility: Not specified for this item; refer to CoA/Spec Sheet and your assay SDSR (study design safety review) for system-specific constraints.

Green Alternatives

As NY2267 is a research small molecule (not a bulk solvent or reagent), green chemistry considerations focus on how it is handled and formulated rather than replacing the molecule itself.

Greener handling strategies (general)

• Solvent minimization: Use the highest feasible stock concentration in DMSO (subject to solubility) to reduce total DMSO volumes dispensed to assays.
• Alternative vehicles: When compatible, explore aqueous solubilization aids (e.g., hydroxypropyl-β-cyclodextrin, minimal amounts of PEG 400, or surfactants) to lower DMSO content in biological assays.
• Microdosing/miniaturization: Adopt low-volume assay formats (e.g., 384- or 1536-well plates) to reduce solvent and waste per data point.
• Closed-loop analytics: Verify compound integrity with UPLC–MS using short gradients to conserve solvents.

Comparison of vehicle options (general, literature)

• DMSO: Broadest solvency; biologically tolerated at ≤0.1–1% final; hygroscopic; not particularly green but used at microliter scales.
• Ethanol: Renewable feedstock potential; more volatile; may perturb membranes/enzymes at modest %.
• Aqueous with cyclodextrin: Reduces organic solvent; may alter apparent potency due to complexation—requires control experiments.

Waste reduction

• Aliquot and store to avoid repeated thaw/heat cycles that cause degradation and disposal of compromised material.

Item-specific eco/tox data: Not specified for this item; consult SDS and institutional green chemistry guidelines for further optimization.

Pharmaceutical Uses

No pharmacopeial status, excipient role, or manufacturing use is specified for this product. It is supplied strictly for research use only.

• Excipient/formulation role: Not specified for this item; refer to CoA/Spec Sheet.
• Compendial listings (USP/EP/JP): Not specified for this item; refer to CoA/Spec Sheet.

General R&D context

• In preclinical research settings, small molecules like NY2267 may be used as tool compounds to interrogate biological pathways. Any formulation for in vivo research should be developed and justified under appropriate IACUC/ethical approvals and safety assessments, using vehicle systems validated for the model.
• If proceeding to regulated development, comprehensive CMC characterization (solid form, polymorph/salt selection, impurity profile) and formal specifications are required—outside the scope of this research listing.

Compliance note

• This item is not intended for use as a drug substance or excipient in humans or animals. No therapeutic claims are made.

Physical Properties

Item-specific physical constants are not provided in the product data. For definitive specifications, consult the CoA/Spec Sheet supplied with your lot.

Item-specific values

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Melting point: Not specified for this item; refer to CoA/Spec Sheet.
• Boiling point: Not specified for this item; refer to CoA/Spec Sheet.
• Density: Not specified for this item; refer to CoA/Spec Sheet.
• Refractive index: Not applicable/unknown for solids; Not specified for this item; refer to CoA/Spec Sheet.
• pKa(s): Not specified for this item; refer to CoA/Spec Sheet.
• logP/logD: Not specified for this item; refer to CoA/Spec Sheet.
• Solubility: Not specified for this item; refer to CoA/Spec Sheet.

General guidance (literature/practice for drug-like small molecules)

• Solubility screening: Begin with anhydrous DMSO to prepare a concentrated primary stock (e.g., 10–50 mM), then dilute into assay buffer. Verify clarity and absence of precipitation upon dilution.
• Aqueous behavior: Many library compounds exhibit limited aqueous solubility; consider co-solvent strategies (≤0.1–1% v/v DMSO in final assay) and surfactant/bovine serum albumin or cyclodextrin if compatible.
• Stability: Unknown for this item. As a precaution, minimize exposure to heat, moisture, and light during handling; confirm stability by LC–MS/UPLC where needed.

Source labeling

• All general values above are literature/practice-based and not item-specific. For lot-specific numeric properties, rely on the CoA/Spec Sheet.

Quality & Grades

Item-specific grade and purity are not provided in the product data.

• Grade/Purity: Not specified for this item; refer to CoA/Spec Sheet.

Context for library/screening compounds (general guidance)

• Typical QC elements: Compound library entries are commonly qualified by LC–MS (identity/purity), proton NMR (structure confirmation), and, where relevant, HRMS. UV purity alone is not sufficient for structural integrity.
• Purity conventions: For screening work, ≥95% purity (by HPLC/UPLC) is commonly targeted, but acceptable thresholds vary by assay and discovery stage. This threshold is not specified for this item; consult the CoA.
• Counter-ions/solvates: Many small molecules are supplied as free bases/acids or as salts/solvates. Verify the exact form (salt, hydrate/solvate content) in the CoA, as it affects molecular weight and dosing.
• Residual solvents/water: Not specified for this item; refer to CoA/Spec Sheet. If critical, quantify by KF/GC as part of incoming QC.

Implications for use

• Dose calculations: Use the exact molecular weight and form from the CoA to prepare accurate stock solutions and assay concentrations.
• Chromatography: If using in analytical methods, obtain the UV spectrum and retention behavior from your system suitability tests, as low-UV impurities may co-elute.

Documentation

• For GLP/QA settings, archive the item-specific CoA/SDS with your batch records. If additional certifications (e.g., trace metals, specific absorbance) are required, request them before use.

Reaction & Applications

This product is positioned as a research small molecule within a compound library rather than as a synthetic reagent. Consequently, its primary applications are in chemical biology and discovery workflows, not as a stoichiometric/catalytic reagent in preparative chemistry.

Discovery and screening use (general guidance)

• Assay development: Employ NY2267 as a test article or reference in high-throughput screening (HTS), hit validation, or mechanistic/phenotypic assays. Ensure precise dosing using CoA-derived molecular weight and confirm solubility in your assay medium.
• SAR exploration: If structural analogs are available, use parallel testing to establish preliminary structure–activity relationships. For this specific item, structural features are not disclosed here; consult public databases (CID 12000419) or the CoA as permitted by your workflow.
• Control experiments: Include vehicle (DMSO) controls at matched percentages and, when possible, orthogonal assay modalities (biochemical vs. cellular) to verify on-target effects versus assay interference.

Assay interference considerations (general)

• Pan-assay interference (PAINS) and redox activity can cause false positives. Use counter-screens (e.g., detergent tolerance, redox scavengers, light-dependent artifacts) and concentration–response curves with careful curve classification.
• Aggregation: Test with low concentrations of nonionic detergent (e.g., 0.01% Tween-20) or dynamic light scattering when feasible.

Item-specific mechanistic role

• Specific target class or mechanism of NY2267: Not specified for this item; refer to CoA/Spec Sheet and literature sources for CAS 886053-73-2 if target data are required.

Reaction Conditions

This section is generally not applicable. NY2267 is supplied as a research small molecule for screening/assay use rather than as a reagent for performing named synthetic reactions.

• Item-specific reactivity, catalysts, and preparative conditions: Not specified for this item; refer to CoA/Spec Sheet.

If using NY2267 in assay workflows (general guidance)

• Stock preparation: Dissolve in anhydrous DMSO at the highest concentration supported by solubility and assay design. Vortex and, if necessary, briefly sonicate; filter through 0.22 μm PTFE if particulate persists.
• Dilution: Add stock to buffer/media with thorough mixing; keep final DMSO constant across conditions.
• Stability checks: Confirm integrity by LC–MS after heating cycles or prolonged storage.

These points are general, literature-based practices for handling screening compounds and are not item-specific reaction conditions.

Safety & Handling

Authoritative safety information resides in the Safety Data Sheet (SDS). The following is general laboratory guidance for handling research small molecules.

Item-specific hazard data

• Signal word: Not specified for this item; refer to SDS.
• GHS hazard statements: Not specified for this item; refer to SDS.
• GHS classification/pictograms: Not specified for this item; refer to SDS.

General precautions (good laboratory practice)

• PPE: Wear lab coat, safety glasses, and appropriate chemical-resistant gloves (e.g., nitrile). Handle powders/solutions in a fume hood to avoid inhalation/ingestion.
• Avoid exposure: Prevent contact with skin, eyes, and clothing. Do not inhale dust, vapors, or aerosols.
• Incompatibilities: Unknown for this item; avoid strong oxidizers and strong acids/bases unless confirmed compatible by SDS/CoA.
• Hygiene: Wash hands thoroughly after handling; do not eat, drink, or smoke in work area.

First-aid overview (general)

• Eye/skin contact: Rinse with water for several minutes; remove contaminated clothing. Seek medical advice if irritation persists.
• Inhalation: Move to fresh air; seek medical attention if symptoms occur.
• Ingestion: Rinse mouth; do not induce vomiting; obtain medical attention.

Spills and waste

• Small spills: Absorb with inert material; dispose in accordance with local regulations.
• Waste: Collect as organic hazardous waste. Do not release to drains.

Special risks

• Unknown specific reactive hazards for this compound. Until SDS is reviewed, treat as potentially harmful/irritant and avoid heating or aerosolization.

Always defer to the item’s SDS for definitive hazard, handling, and emergency information.

Solvent Selection

Because the structure and polarity of NY2267 are not provided, solvent choice should be established empirically, starting with broadly compatible research solvents.

General recommendations (literature/practice for drug-like small molecules)

• Primary stock solvent: Anhydrous DMSO is the default for screening compounds due to broad solvency, low volatility, and biological assay compatibility at ≤0.1–1% v/v final concentration.
• Secondary options: DMF, ethanol (EtOH), methanol (MeOH), or acetonitrile (MeCN) can be evaluated if DMSO is unsuitable for a specific assay.
• Aqueous dilution: Dilute DMSO stocks into buffered aqueous media (e.g., PBS, HEPES, cell culture media) with gentle mixing. Add compound stock last to minimize local supersaturation and precipitation.
• Solubility testing: Prepare a solubility ladder (e.g., 1, 5, 10, 25, 50 mM in DMSO) and visually inspect for clarity; confirm by UPLC if critical.

Practical considerations

• Light/moisture sensitivity: Unknown for this item; handle under ambient light unless your analytics indicate photolability. Minimize water uptake in hygroscopic solvents (cap DMSO containers promptly).
• Adsorption: Hydrophobic and cationic molecules may adsorb to plastic; use low-binding tips/plates or glass vials if recovery is poor.

Quick comparison (general)

• DMSO: Highest solvency; biologically tolerated at low %; hygroscopic.
• EtOH/MeOH: Volatile; assay-compatible up to modest %; may affect enzyme activity.
• MeCN: Good solvency; volatile; limited compatibility in live-cell assays.

Item-specific solvent/miscibility data: Not specified for this item; refer to CoA/Spec Sheet.

Storage & Reconstitution

Item-specific conditions

• Storage temperature: Store at -80°C (item-specific fact).
• Shipped in: Dry ice packs + Cold packs (item-specific fact).

General best practices for small-molecule library compounds

• As-received form: If supplied as dry solid, keep container tightly closed under dry, inert atmosphere where feasible. If supplied as a DMSO solution, keep frozen and protected from moisture ingress.
• Aliquoting: Upon first opening, divide into single-use aliquots to minimize freeze–thaw cycles and headspace moisture. Label aliquots with lot, concentration (if in solution), solvent, and date.
• Thawing: Thaw on ice or at room temperature; mix thoroughly before use. Avoid repeated temperature cycling.
• Light and moisture: Specific sensitivities are not disclosed. As a precaution, protect from excessive light and humidity during handling.

Reconstitution (if provided as a solid)

• Solvent choice: Start with anhydrous DMSO to prepare a concentrated stock. Confirm solubility visually and, if critical, by analytical methods.
• Filtration: If particulates persist after dissolution, pass through a 0.22 μm PTFE filter into clean, dry vials.

Stability and retest

• Item-specific shelf life/retest date: Not specified for this item; refer to CoA/Spec Sheet.
• Monitor integrity by periodic LC–MS/UPLC, particularly after extended storage or any accidental warming event.

Note: For research use only. Always consult the item’s CoA and SDS for definitive storage and handling guidance.

Structure & Identity

Brief overview: NY2267 (CAS 886053-73-2) is listed as a small-molecule research item within a screening/compound library context. Structural identifiers are not provided in the product data.

• Product name: NY2267
• SKU: N656758
• CAS: 886053-73-2 (item-specific fact)
• PubChem CID: 12000419 (item-specific fact)
• InChIKey: Not specified for this item; refer to CoA/Spec Sheet.
• SMILES: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular formula: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular weight: Not specified for this item; refer to CoA/Spec Sheet.

Structural features

• Item-specific structural description (functional groups, ring systems, stereochemistry): Not specified for this item; refer to CoA/Spec Sheet.

2D structure (descriptive)

• Not available from provided data. Without SMILES/InChI, a defensible 2D description cannot be given. Please consult the Certificate of Analysis (CoA), specification sheet, or public database record (CID 12000419) if structure disclosure is required for your workflow.

Notes

• Category: Small molecule/compound library entry (Manufacturer category path).
• Research use only: For research use only (not for human or veterinary applications).

Synthetic Utility

NY2267 is offered as a research small molecule in a compound library context and is not positioned as a synthetic building block or reagent.

• Functional groups and reactivity: Not specified for this item; refer to CoA/Spec Sheet for any structural clues if derivatization is contemplated.
• Typical transformations: Not applicable without structural disclosure. Routine synthetic manipulations (e.g., cross-couplings, amide formations) may or may not be feasible depending on the unknown functionality.

General guidance (if derivatization is needed for probe development)

• Analytical first: Confirm structure and purity by NMR and HRMS prior to attempting any semisynthetic modification.
• Handle with care: Unknown stability toward acid/base/oxidation requires conservative conditions (room temperature, neutral pH) in preliminary tests.
• Tagging strategies: If biotinylation/fluorophore tagging is desired for chemoproteomics, identify latent handles (amines, acids, phenols) from structural data (not provided here) and use linkers that minimize perturbation.

Bottom line

• Synthetic utility for this specific item is limited by the absence of disclosed structure in the present data. Treat it primarily as a test article for biological/analytical studies rather than a general-purpose reagent.

Target Specificity

Not applicable. NY2267 is not an antibody, protein, or nucleic acid probe with defined epitope/sequence specificity in this listing.

• Target, selectivity profile, and binding constants for NY2267: Not specified for this item; refer to CoA/Spec Sheet and literature associated with CAS 886053-73-2 or CID 12000419 if target information is required.

Use in discovery

• If used as a putative modulator, evaluate specificity by testing against panels of related targets and orthogonal assays to rule out assay interference.

Frequently Asked Questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 886053-73-2, the molecular formula is C38H43N3O6, and the molecular weight is 637.76 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.