p-Chlorotoluene - CP, ≥97% , CAS No.106-43-4

CAS: 106-43-4 Cat. No.: C104629 Molecular Weight: 126.59 Beilstein Registry Number: 1903635 EC Number: 203-397-0
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GRADE & PURITY CP ? Chemically Pure grade — moderate purity above technical grade but below analytical. Use for general lab reactions where ultra-low impurities aren't critical. ≥97%
Synonyms
4-methylchlorobenzene | 4-methyl-chlorobenzene | DTXCID904814 | p-Chlorotoluene [UN2238] [Flammable liquid] | AKOS000120044 | S0660 | Tox21_201408 | STL280325 | CAS-106-43-4 | FT-0659662 | Q8R236H42N | 4-Chloro-1-methylbenzene | 1-chloranyl-4-methyl-benz
Storage
Room temperature
Shipped In
FedEx DG Service
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Size
Status
Price
Qty
100ml
C104629-100ml
9
$9.90
500ml
C104629-500ml
2
$31.90
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Why this grade

CP, ≥97% CP for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 15 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
4-methylchlorobenzene | 4-methyl-chlorobenzene | DTXCID904814 | p-Chlorotoluene [UN2238] [Flammable liquid] | AKOS000120044 | S0660 | Tox21_201408 | STL280325 | CAS-106-43-4 | FT-0659662 | Q8R236H42N | 4-Chloro-1-methylbenzene | 1-chloranyl-4-methyl-benz
Specifications & Purity
CP, ≥97%
Storage
Room temperature
Shipped In
FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
CP
Purity
≥97%
Names and Identifiers
Canonical SmilesCC1=CC=C(C=C1)Cl
IUPAC Name1-chloro-4-methylbenzene
InChIKeyNPDACUSDTOMAMK-UHFFFAOYSA-N
INCHI1S/C7H7Cl/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
Isomeric SMILES CC1=CC=C(C=C1)Cl
WGK Germany 1
UN Number 2238
Packing Group III
Molecular Weight 126.59
Beilstein 1903635
Reaxy-Rn 1903635
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1903635&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClassBenzene and substituted derivatives
SubclassHalobenzenes
Intermediate Tree Nodes Not available
Direct ParentChlorobenzenes
Alternative Parents Toluenes  Aryl chlorides  Organochlorides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Toluene - Chlorobenzene - Aryl halide - Aryl chloride - Hydrocarbon derivative - Organochloride - Organohalogen compound - Aromatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as chlorobenzenes. These are compounds containing one or more chlorine atoms attached to a benzene moiety.
External Descriptors a small molecule
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
C2610221Certificate of AnalysisMar 13, 2026 C104629
E1810062Certificate of AnalysisJan 05, 2026 C104629
K2129449Certificate of AnalysisSep 08, 2025 C104629
K2129450Certificate of AnalysisSep 08, 2025 C104629
C1519004Certificate of AnalysisNov 11, 2022 C104629
B2512053Certificate of AnalysisDec 07, 2021 C104629
B2512054Certificate of AnalysisDec 07, 2021 C104629
C23201122Certificate of AnalysisDec 07, 2021 C104629
Chemical and Physical Properties
SolubilityInsoluble in water, soluble in ethanol, chloroform, acetic acid, and miscible in ether.
Refractive Index1.52
Flash Point(°F)11 °C
Flash Point(°C)11°C
Boil Point(°C)162°C
Melt Point(°C)6-8 °C
Molecular Weight126.580 g/mol
XLogP33.300
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass126.024 Da
Monoisotopic Mass126.024 Da
Topological Polar Surface Area0.000 Ų
Heavy Atom Count8
Formal Charge0
Complexity62.800
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Xiaoying Feng, Yixin Kuang, Suxin Zhou, Juan Zheng, Gangfeng Ouyang.  (2023)  New insights into the effects of isomeric chlorine substitution on microstructures and enrichment capacities of functionalized polystyrene nanospheres.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.146887]
2. Yong Wei, Chunbiao Liu, Yonghui Zhang, Chen Shi, Yixiong Tang, Chunlan Liu, Yudong Su, Chen Wang, Yu Zhang, Zhihai Liu.  (2023)  All-Fiber SPR Microfluidic Chip for Arctigenin Detection.  IEEE SENSORS JOURNAL,  23  (12): (12838-12844).  [PMID:] [10.1109/JSEN.2023.3269032]
3. Lei Yuan, Cai Xu, Shaoyong Zhang, Mincheng Yu, Xiaozhong Wang, Yingqi Chen, Liyan Dai.  (2023)  Role of oxygen vacancy in spinel (FeCoNiCrMn)3O4 high entropy oxides prepared via two different methods for the selective CH bond oxidation of p-chlorotoluene.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:36867932] [10.1016/j.jcis.2023.02.128]
4. Lijing Zhang, Jiaqi Han, Yuchao Wang, Wenbo Yang, Shengyang Tao.  (2022)  Pd/Mg(OH)2/MgO–ZrO2 Nanocomposite Systems for Highly Efficient Suzuki–Miyaura Coupling Reaction at Room Temperature: Implications for Low-Carbon Green Organic Synthesis.  ACS Applied Nano Materials,      [PMID:] [10.1021/acsanm.2c01179]
5. Jie Deng, Wanying Lei, Junwei Fu, Huile Jin, Quanlong Xu, Shun Wang.  (2022)  Enhanced Selective Photooxidation of Toluene to Benzaldehyde over Co3O4-Modified BiOBr/AgBr S-Scheme Heterojunction.  Solar RRL,  (8): (2200279).  [PMID:] [10.1002/solr.202200279]
6. Jie Yang, Liyuan Huai, Jiang Gan, Hualei Hu, Shenghu Zhou, Jian Zhang.  (2021)  Self-Etherification of 5-Hydroxymethylfurfural to 5,5′(Oxy-bis(methylene))bis-2-furfural over Hierarchically Micromesoporous ZSM-5: The Role of Brønsted- and Lewis-Acid Sites.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.1c03337]
7. Xue Li, Yuan-Yuan Cui, Cheng-Xiong Yang.  (2020)  Covalent coupling fabrication of microporous organic network bonded capillary columns for gas chromatographic separation.  TALANTA,      [PMID:33379116] [10.1016/j.talanta.2020.121914]
8. Ke Bei, Chuanyong Zhang, Junliang Wang, Kai Li, Jinghui Lyu, Jia Zhao, Jie Chen, I-Ming Chou, Zhiyan Pan.  (2016)  Solubility and dissolution mechanism of 4-chlorotoluene in subcritical water investigated in a fused silica capillary reactor by in situ Raman spectroscopy.  FLUID PHASE EQUILIBRIA,      [PMID:] [10.1016/j.fluid.2016.05.018]
9. Xi Zhang, Xiaohuan Zang, Guijiang Zhang, Chun Wang, Zhi Wang.  (2015)  Application of mesoporous carbon as a solid-phase microextraction fiber coating for the extraction of volatile aromatic compounds.  JOURNAL OF SEPARATION SCIENCE,  38  (16): (2880-2886).  [PMID:26041569] [10.1002/jssc.201500304]
10. Yang Liu, Jian Li, Jiawei Liu, Changwei Tang, Quan Bai.  (2024)  Fabrication of hierarchically porous University of Oslo-66@silica shell-core stationary phase by phosphoric acid etching strategy for enhanced separation performance in liquid chromatography.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111110]
11. Shandi Zhong, Cai Xu, Quanfu Long, Hang Zhou, Jianhai Yang, Jia Guo, Xiaozhong Wang, Liyan Dai.  (2024)  Highly catalytic performance for the selective C–H bond oxidation of p-chlorotoluene over Co, Cr co-doped OMS-2 catalyst.  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2024.120789]
12. Zeqi Wu, Feng Niu, Wenhao Yao, Siyuan Gao, Da Chen, Yuexiang Huang.  (2024)  Photocatalytic Selective Oxidation of Toluene over Chlorine-Coordinated MIL-101(Fe) under Ambient Conditions.  LANGMUIR,      [PMID:39312413] [10.1021/acs.langmuir.4c02431]
13. Wen-Chao Deng, Hai-Long Qian, Cheng Yang, Shu-Ting Xu, Xiu-Ping Yan.  (2023)  General Two-Step Method for the Fabrication of Covalent-Organic Framework-Bound Open-Tubular Capillary Columns for High-Resolution Gas Chromatography Separation of Isomers.  ACS Applied Materials & Interfaces,      [PMID:37963803] [10.1021/acsami.3c13853]
14. Jinhua Xu, Minghui Tang, Jinyu Zhang, Wenmin Zhang, Shiye Xie, Lan Zhang.  (2025)  Green and Controlled Synthesis of Copper-Based Tryptophan Flower-like Chiral Metal-Organic Framework for Enantioselective Recognition and Volatile Organic Compound Separation.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:40339186] [10.1016/j.chroma.2025.466020]
15. Hong-Mei Fu, Xi-Peng Zhang, Shi-Chao Qi, Ding-Hua Liu.  (2025)  Efficient liquid-phase adsorptive separation between p- and m-Chlorotoluene by a metal-organic framework Mn-dhbq.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.135978]
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