Pemetrexed hydrate - ≥98%, contains

CAS: 137281-23-3(anhy) Cat. No.: P1493015 Formula: C₂₀H₂₁N₅O₆·xH₂O Molecular Weight: 427.41（anhy） EC Number: 680-625-9

GRADE & PURITY ≥98%, contains <4%EtOH

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Overview

Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

Specifications

Specifications & Purity

≥98%, contains <4%EtOH

Biochemical and Physiological Mechanisms

High affinity dihydrofolate reductase inhibitor (Ki= 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Kivalues are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits prolife

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Molecular Weight: 427.41（anhy）

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 42.74, Max Conc. mM: 100
• Sensitivity: Heat Sensitive;light sensitive