Phenytoin - Moligand™, 10mM in DMSO , Channel blocker of Na v1.2, CAS No.57-41-0, Channel blocker of Na v1.2

CAS: 57-41-0 Cat. No.: P408649 Formula: C₁₅H₁₂N₂O₂ Molecular Weight: 252.27 EC Number: 200-328-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Diphenylhydantoin | 5,​5-​diphenyl-2,​4-​imidazolidinedione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Phenytoin Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.
In vitro

In vivo

Cell Data

cell lines：MM.1S, MM.1R, RPMI8226, U266, RPMI8266, RPMI-Dox40, OPM1 cells, primary MM cells and PBMNCs

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Diphenylhydantoin | 5,​5-​diphenyl-2,​4-​imidazolidinedione

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

CHANNEL BLOCKER

Mechanism of action

Channel blocker of Na v1.2

Product Properties

• ALogP: 2.5

Names and Identifiers

• Isomeric SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
• UN Number: 2811
• Packing Group: I
• Molecular Weight: 252.27
• Reaxy-Rn: 384532
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=384532&ln=

Associated Targets(Human)

SCN2A Tclin Sodium channel protein type 2 subunit alpha (2 Activities)

Discover Target: SCN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Melt Point(°C): 293-295 °C

References

1. De Bai, Haowei Chen, Lijuan Liu, Nanxi Xiang, Jichuan Zhang, Chengyu Wu, Jiaheng Zhang, Fang Wang.  (2023)  Ionic liquid microcapsules for the topical delivery of pterostilbene: Enhanced transdermal delivery and anti-wrinkle and skin brightening effects.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2023.123842]

2. Yuxuan Lin, Weihua Qin, Yuwei Lu, Mingye Ren, Pan Gao, Feng Xiao, Shaoxia Yang.  (2023)  Reconstructing atomic Fe coordination in the PMS activation process to realize efficient BPA degradation at low temperature.  Environmental Science-Nano,  10  (5): (1284-1296).  [PMID:] [10.1039/D2EN01156E]

3. Wei Li, Zhen Wang, Xiaoyu Wang, Xiaowei Cao, Caili Bi, Lili Jiang, Shuna Cui, Yong Liu.  (2021)  Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:33961833] [10.1016/j.cbi.2021.109498]

4. Mengtian Jia, Yanyan Zhu, Dong Guo, Xiaogang Bi, Xiaohong Hou.  (2020)  Surface molecularly imprinted polymer based on core-shell Fe3O4@MIL-101(Cr) for selective extraction of phenytoin sodium in plasma.  ANALYTICA CHIMICA ACTA,      [PMID:32825905] [10.1016/j.aca.2020.06.075]

5. Jing-Xian Zhang, Mei-Juan Qi, Mei-Zhi Shi, Jun-Jun Chen, Xiang-Qi Zhang, Jiao Yang, Ke-Zhi Zhang, Yong-Long Han, Cheng Guo.  (2018)  Effects of Danhong injection, a traditional Chinese medicine, on nine cytochrome P450 isoforms in vitro.  BIOMEDICAL CHROMATOGRAPHY,  33  (4): (e4454).  [PMID:30520061] [10.1002/bmc.4454]

6. Suqian Xu, Hanxu Zhu, Wenrui Cao, Zhibin Wen, Jinnan Wang, Corvini Philippe François-Xavier, Thomas Wintgens.  (2018)  Cu-Al2O3-g-C3N4 and Cu-Al2O3-C-dots with dual-reaction centres for simultaneous enhancement of Fenton-like catalytic activity and selective H2O2 conversion to hydroxyl radicals.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2018.04.029]

7. Wang Weixue, Liu Yang, Du Xinjie, Wang Huihui, Ai Yuejie, Liu Qianwei, Wang Xiangke, Chen Zhe.  (2025)  Solvent-free fabrication of ultrathin two-dimensional metal oxides/sulfides in a fixed interlayer by geometric confinement.  Nature Communications,  16  (1): (1-11).  [PMID:39948342] [10.1038/s41467-025-56912-9]

Frequently Asked Questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 57-41-0, the molecular formula is C15H12N2O2, and the molecular weight is 252.27 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.