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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog ( Hh ) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC 50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC 50 values of 5.7 and 6.8 μM, respectively.
| Canonical Smiles | CC12CC3C4(C56C1C(=O)C(O5)(C7CC(C8(CC=CC(=O)C8(C7CCC6(C(=O)O4)O)C)Cl)O)OCC2C(=O)O3)C |
|---|---|
| IUPAC Name | 14-chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone |
| InChIKey | YNEPXUIPALKHAU-UHFFFAOYSA-N |
| INCHI | 1S/C28H31ClO10/c1-22-10-17-24(3)28-18(22)19(32)27(39-28,36-11-14(22)20(33)37-17)13-9-16(31)25(29)7-4-5-15(30)23(25,2)12(13)6-8-26(28,35)21(34)38-24/h4-5,12-14,16-18,31,35H,6-11H2,1-3H3 |
| Isomeric SMILES | CC12CC3C4(C56C1C(=O)C(O5)(C7CC(C8(CC=CC(=O)C8(C7CCC6(C(=O)O4)O)C)Cl)O)OCC2C(=O)O3)C |
| Alternate CAS | 70241-09-7 |
| PubChem CID | 155551 |
| MeSH Entry Terms | 6,7-dehydrophysalin H;6-deoxyphysalin H;physalin H |
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