average Mv 300,000, crystalline for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Solid Poly(2-hydroxyethyl methacrylate) (pHEMA) is brittle, while pHEMA hydrogel is a soft material. Glass transition temperature for pHEMA hydrogels is reduced by increasing a content of water in the matrix. Macromolecular properties in pHEMA are characterized by non-covalent interactions of hydrogen-bonds among the polymer chains as well as the hydrated water molecules. The presence of polar groups of hydroxyl and carboxyl on each repeat unit makes this polymer compatible with water. The hydrophobic a-methyl groups of the backbone convey hydrolytic stability to the polymer and enhance mechanical strength of the polymer matrix.
Application
pHEMA scaffolds are used in tissue engineering. It can be used in hydrogels for biomedical applications, as sorbents for metal ions.pHEMA has been used in applications such as soft contact lenses, in drug delivery systems, and in kidney dialysis membranes.Nanoparticles of pHEMA may be employed as a carrier for controlled delivery of anticancer and antitumor drugs.
| Pubchem Sid | 488199675 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488199675 |
| Canonical Smiles | CC(=C)C(=O)OCCO |
| IUPAC Name | 2-hydroxyethyl 2,2-dimethylbutanoate |
| InChIKey | CRUFITZJZGASJI-UHFFFAOYSA-N |
| INCHI | 1S/C8H16O3/c1-4-8(2,3)7(10)11-6-5-9/h9H,4-6H2,1-3H3 |
| Isomeric SMILES | CCC(C)(C)C(=O)OCCO |
| Reaxy-Rn | 1071583 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1071583&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Fatty Acyls |
| Subclass | Fatty acid esters |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Fatty acid esters |
| Alternative Parents | Carboxylic acid esters Monocarboxylic acids and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Fatty acid ester - Carboxylic acid ester - Monocarboxylic acid or derivatives - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Primary alcohol - Organooxygen compound - Carbonyl group - Alcohol - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as fatty acid esters. These are carboxylic ester derivatives of a fatty acid. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 H2328485 | Certificate of Analysis | Jun 09, 2026 | P432413 |
| H2328486 | Certificate of Analysis | Jun 09, 2026 | P432413 |
| H2328487 | Certificate of Analysis | Jun 09, 2026 | P432413 |
| I2508634 | Certificate of Analysis | Aug 20, 2025 | P432413 |
| I2508635 | Certificate of Analysis | Aug 20, 2025 | P432413 |
| H2328674 | Certificate of Analysis | Jul 19, 2023 | P432413 |
| Flash Point(°C) | 97.2℃ |
|---|---|
| Boil Point(°C) | 189°C at 760 mmHg |
| Molecular Weight | 160.210 g/mol |
| XLogP3 | 1.200 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 160.11 Da |
| Monoisotopic Mass | 160.11 Da |
| Topological Polar Surface Area | 46.500 Ų |
| Heavy Atom Count | 11 |
| Formal Charge | 0 |
| Complexity | 129.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Chao Zhang, Donglin Xia, Jiahao Liu, Da Huo, Xiqun Jiang, Yong Hu. (2020) Bypassing the Immunosuppression of Myeloid-Derived Suppressor Cells by Reversing Tumor Hypoxia Using a Platelet-Inspired Platform. ADVANCED FUNCTIONAL MATERIALS, 30 (22): (2000189). [PMID:] [10.1002/adfm.202000189] |
| 2. Ying Shi, Hongda An, Wenshuang Wang, Dong Nan, Yingzhe Cui, Mingyuan He, Jianxiu Lian, Xiaoxiao Zhang, Jing Peng, Xiuhua Yang, Pengfei Liu. (2025) Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis. Translational Oncology, [PMID:41056688] [10.1016/j.tranon.2025.102552] |
