Pomalidomide-C₉-CO₂H - ≥95% , CAS No.2243000-24-8

CAS: 2243000-24-8 Cat. No.: P463440 Formula: C₂₃H₂₉N₃O₆ Molecular Weight: 443.49 PubChem CID: 139035939

GRADE & PURITY ≥95%

Synonyms

Protein degrader building block for PROTAC research, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader, 10-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decanoic acid

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Description

Protein degrader builiding block Pomalidomide-C9-CO2H enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Synonyms

Protein degrader building block for PROTAC research, Crosslinker−E3 Ligase ligand conjugate, Template for synthesis of targeted protein degrader, 10-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)decanoic acid

Specifications & Purity

≥95%

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

Canonical Smiles

C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCCCCC(=O)O

IUPAC Name

10-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]decanoic acid

InChIKey

BGTVAMUEPLYYJY-UHFFFAOYSA-N

INCHI

1S/C23H29N3O6/c27-18-13-12-17(21(30)25-18)26-22(31)15-9-8-10-16(20(15)23(26)32)24-14-7-5-3-1-2-4-6-11-19(28)29/h8-10,17,24H,1-7,11-14H2,(H,28,29)(H,25,27,30)

PubChem CID

139035939

Molecular Weight

443.49

Chemical and Physical Properties

• Flash Point(°F): Not applicable
• Flash Point(°C): Not applicable

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2243000-24-8, the molecular formula is C23H29N3O6, and the molecular weight is 443.49 g/mol. InChIKey BGTVAMUEPLYYJY-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.