Prednisolone disodium phosphate - Moligand™, 10 mM in Water , CAS No.125-02-0

CAS: 125-02-0 Cat. No.: P1499394 Formula: C₂₁H₂₇Na₂O₈P Molecular Weight: 484.39 EC Number: 204-722-9 PubChem CID: 441409

GRADE & PURITY Moligand™, 10 mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.Target: Glucocorticoid Receptor Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others . Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced .

Specifications

Specifications & Purity

Moligand™, 10 mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)COP(=O)([O-])[O-])O)CCC4=CC(=O)C=C[C@]34C)O.[Na+].[Na+]
• RTECS: TU4153300
• PubChem CID: 441409
• Molecular Weight: 484.39
• Reaxy-Rn: 4795229

Chemical and Physical Properties

• Specific Rotation[α]: 99° (C=1,pH 7.0 Buffer sol.)