Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 17 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Prednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound
Downregulates TNF-α production and NF-κB expression
| ALogP | 1.5 |
|---|
| Pubchem Sid | 504750953 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504750953 |
| Canonical Smiles | CC12CC(=O)C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C |
| IUPAC Name | (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione |
| InChIKey | XOFYZVNMUHMLCC-ZPOLXVRWSA-N |
| INCHI | 1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 |
| Isomeric SMILES | C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C |
| WGK Germany | 3 |
| RTECS | TU4154100 |
| Alternate CAS | 53-03-2 |
| NSC Number | 10023 |
| MeSH Entry Terms | Acsis, Prednison;Apo-Prednisone;Cortan;Cortancyl;Cutason;Dacortin;Decortin;Decortisyl;Dehydrocortisone;delta-Cortisone;Deltasone;Encorton;Encortone;Enkortolon;Kortancyl;Liquid Pred;Meticorten;Orasone;Panafcort;Panasol;Predni Tablinen;Prednidib;Predniment; |
| Molecular Weight | 358.43 |
| Beilstein | 2065301 |
| Reaxy-Rn | 29841917 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29841917&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Lipids and lipid-like molecules |
| Class | Steroids and steroid derivatives |
| Subclass | Hydroxysteroids |
| Intermediate Tree Nodes | Not available |
| Direct Parent | 21-hydroxysteroids |
| Alternative Parents | Gluco/mineralocorticoids, progestogins and derivatives 20-oxosteroids 3-oxo delta-1,4-steroids 17-hydroxysteroids 11-oxosteroids Delta-1,4-steroids Tertiary alcohols Alpha-hydroxy ketones Cyclic ketones Cyclic alcohols and derivatives Primary alcohols Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aliphatic homopolycyclic compounds |
| Substituents | 21-hydroxysteroid - Progestogin-skeleton - Pregnane-skeleton - 20-oxosteroid - 3-oxo-delta-1,4-steroid - 3-oxosteroid - 17-hydroxysteroid - Oxosteroid - 11-oxosteroid - Delta-1,4-steroid - Alpha-hydroxy ketone - Tertiary alcohol - Cyclic alcohol - Cyclic ketone - Ketone - Organic oxygen compound - Organooxygen compound - Primary alcohol - Carbonyl group - Hydrocarbon derivative - Alcohol - Organic oxide - Aliphatic homopolycyclic compound |
| Description | This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. |
| External Descriptors | C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 15, 2026 | P116562 | |
| Certificate of Analysis | Jun 15, 2026 | P116562 | |
| Certificate of Analysis | Jun 08, 2026 | P116562 | |
| Certificate of Analysis | Jun 08, 2026 | P116562 | |
| Certificate of Analysis | Jun 08, 2026 | P116562 | |
| Certificate of Analysis | Jun 08, 2026 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 | |
| Certificate of Analysis | Aug 04, 2022 | P116562 |
| Solubility | DMSO 72 mg/mL (200 mM); Water <1 mg/mL (<1 mM), |
|---|---|
| Melt Point(°C) | 233-235°C |
| Molecular Weight | 358.400 g/mol |
| XLogP3 | 1.500 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 358.178 Da |
| Monoisotopic Mass | 358.178 Da |
| Topological Polar Surface Area | 91.700 Ų |
| Heavy Atom Count | 26 |
| Formal Charge | 0 |
| Complexity | 764.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 6 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
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| 3. Yan Xiang, Zhang Yayue, Lang Haiyan, Huang Ziming, Chen Xinyi, He Hao, Zhao Qian, Wang Jun. (2023) Research on the mechanism of prednisone in the treatment of ITP via VIP/PACAP-mediated intestinal immune dysfunction. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 28 (1): (1-9). [PMID:36750876] [10.1186/s40001-023-00987-x] |
| 4. Yan Wu, Panpan Cao, Yanhao Jiang, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Ingenious introduction of aminopropylimidazole to tune the hydrophobic selectivity of dodecyl-bonded stationary phase for environmental organic pollutants. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2022.107933] |
| 5. Changfeng Hu, Jida Zhang, Suzhen Hong, Haichang Li, Lu Lu, Guanqun Xie, Wenqing Luo, Yu Du, Zhijun Xie, Xianlin Han, Chengping Wen. (2020) Oxidative stress-induced aberrant lipid metabolism is an important causal factor for dysfunction of immunocytes from patients with systemic lupus erythematosus. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:33352222] [10.1016/j.freeradbiomed.2020.12.006] |
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| 7. Youfang Huang, Yanyun Li, Qing Luo, Xiaojia Huang. (2020) One-step preparation of functional groups-rich graphene oxide and carbon nanotubes nanocomposite for efficient magnetic solid phase extraction of glucocorticoids in environmental waters. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2020.126785] |
| 8. Zheng Kai, Jia Jia, Yan Shihai, Shen Hong, Zhu Ping, Yu Jiangyi. (2020) Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated TH17/Treg balance. INFLAMMOPHARMACOLOGY, 28 (6): (1705-1716). [PMID:32472435] [10.1007/s10787-020-00722-6] |
| 9. Huijuan Wang, Tingting Feng, Donggui Guo, Min Zhang, Lin Chen, Ying Zhou. (2018) Sanggenon C Stimulates Osteoblastic Proliferation and Differentiation, Inhibits Osteoclastic Resorption, and Ameliorates Prednisone-Induced Osteoporosis in Zebrafish Model. MOLECULES, 23 (9): (2343). [PMID:30217005] [10.3390/molecules23092343] |
| 10. Xiuqing Zhang, Ting Liu, Xiaohui Fan, Ni Ai. (2017) In silico modeling on ADME properties of natural products: Classification models for blood-brain barrier permeability, its application to traditional Chinese medicine and in vitro experimental validation. JOURNAL OF MOLECULAR GRAPHICS & MODELLING, [PMID:28628860] [10.1016/j.jmgm.2017.05.021] |
| 11. Yuan Huang, Zhiqun Zheng, Liying Huang, Hong Yao, Xiao shan Wu, Shaoguang Li, Dandan Lin. (2017) Optimization of dispersive liquid-phase microextraction based on solidified floating organic drop combined with high-performance liquid chromatography for the analysis of glucocorticoid residues in food. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:28259095] [10.1016/j.jpba.2017.02.026] |
| 12. Xin Wang, Feiyang Pu, Xuanye Yang, Xili Feng, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiao-Xia Ma, Xiao-Ming Yang. (2024) Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition on nucleic acid synthesis, mRNA splicing and protein stability. Virulence, [PMID:38170681] [10.1080/21505594.2023.2301242] |
| 13. Kaixing Luo, Yu Luo, Yanjuan Liu, Yuefei Zhang, Wei Chen, Zhengwu Bai, Sheng Tang. (2022) Hydrophobic and hydrophilic selectivity of a multifunctional carbonyldiimidazolium/dodecyl modified silica stationary phase. JOURNAL OF CHROMATOGRAPHY A, [PMID:35810643] [10.1016/j.chroma.2022.463300] |
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| 15. Zhi-Peng Li, Chen-Ri Su, Long-Xin Yang, Han-Yue Li, Han Zhang, Ji-Fei Yang, Xian-Hua Wang, Yun-Chao Liu, Rui-Xue Ran. (2025) Facile construction of hydrophilic core-shell structured magnetic covalent organic framework for efficient magnetic solid-phase extraction of five glucocorticoids from milk sample. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:41092886] [10.1016/j.jchromb.2025.124822] |
| 16. Jie Bai, Ying Bao, Shan Li, Zicheng Guo, Jie Xu, Rong Huang, Jing Yang, Cunqin Lv, Jianhong Liu, Dinglin Zhang. (2026) Tailorable Metal–Polyphenol Nanoparticles for Targeted Treatment of Inflammatory Bowel Disease. ACS Biomaterials Science & Engineering, [PMID:41732806] [10.1021/acsbiomaterials.5c02094] |
| 17. Xiaoli Zhou, Xinyue Yan, Xiaofeng Liang, Ziyi Zhao, Yong Huang, Kun Hu. (2026) Ionic liquid–assisted synthesis of triazine covalent organic frameworks for selective enrichment and sensitive detection of nonsteroidal anti-inflammatory drugs in urine and river water. ANALYTICA CHIMICA ACTA, [PMID:] [10.1016/j.aca.2026.345325] |
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