(–)-PSI Reagent - ≥95% , CAS No.2245335-70-8

CAS: 2245335-70-8 Cat. No.: P467206 Formula: C₁₆H₁₆F₅OPS₃ Molecular Weight: 446.46 PubChem CID: 146660239

GRADE & PURITY ≥95%

Synonyms

(–)-Ψ, (2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, Phosphorus-Sulfur Incorporation Reagent

Storage

Room temperature

Overview

Description

Air- and moisture-tolerant, this (-)-PSI Reagent was developed in theBaran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat#ALD00604).The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by theBaranlab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Specifications

Synonyms

(–)-Ψ, (2S,3aS,6R,7aS)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, Phosphorus-Sulfur Incorporation Reagent

Specifications & Purity

≥95%

Legal Information

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

Storage

Room temperature

Purity

≥95%

Names and Identifiers

• Canonical Smiles: CC(=C)C1CCC2(C(C1)OP(=S)(S2)SC3=C(C(=C(C(=C3F)F)F)F)F)C
• IUPAC Name: (3aS,6R,7aS)-3a-methyl-2-(2,3,4,5,6-pentafluorophenyl)sulfanyl-6-prop-1-en-2-yl-2-sulfanylidene-5,6,7,7a-tetrahydro-4H-benzo[d][1,3,2]oxathiaphosphole
• InChIKey: YPYCUYPOHPPYAS-QSHUGKRNSA-N
• INCHI: 1S/C16H16F5OPS3/c1-7(2)8-4-5-16(3)9(6-8)22-23(24,26-16)25-15-13(20)11(18)10(17)12(19)14(15)21/h8-9H,1,4-6H2,2-3H3/t8-,9+,16+,23?/m1/s1
• PubChem CID: 146660239
• Molecular Weight: 446.46

Chemical and Physical Properties

• Flash Point(°F): Not applicable
• Flash Point(°C): Not applicable
• Melt Point(°C): 103-107℃