QM31 - ≥98% , CAS No.937735-00-7
In stock
SKU
Q648691
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC 50 =7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint.
In Vitro
SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC 50 of 5 μM in HeLa S100 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
More Information
| CAS | 937735-00-7 |
|---|---|
| Specifications & Purity | ≥98% |
| Storage | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC 50 =7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. In Vitro SVT016426 (0.5-2 μM) inhibits Apaf1-induced activation of caspase activity with an IC 50 of 5 μM in HeLa S100 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| Solubility | DMSO : 125 mg/mL (162.64 mM; Need ultrasonic) |
| PubChem CID | 16739770 |
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