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≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively.
Appearance:Solid
IC50& Target:hNPFF1R 58 nM (Ki) hNPFF2R 75 nM (Ki)
In Vitro:RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo:RF9 (0.1mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoke
Biological Activity:RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively .
| Canonical Smiles | NC(C(CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC(C23C[C@H](C4)CC(C[C@@H]4C3)C2)=O)=O)=O.Cl |
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| Molecular Weight | 519.08 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Solubility | DMSO : 50 mg/mL (96.32 mM; Need ultrasonic) |
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