Rutaecarpine - 10mM in DMSO , CAS No.84-26-4

CAS: 84-26-4 Cat. No.: R408599 Formula: C₁₈H₁₃N₃O Molecular Weight: 287.32 EC Number: 635-907-6 PubChem CID: 65752

GRADE & PURITY 10mM in DMSO

Synonyms

Rutecarpine | Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class ofCOX-2inhibitor.
In vitro

Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems.

In vivo

LD50: Mice 65mg/kg (i.v.).
Cell Data

cell lines：Ba/F3 cells and primary Ph⁺ leukemia cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Rutecarpine | Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 8,13-dihydro-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Rutaecarpine (Rutecarpine) is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs; a new class of COX-2 inhibitor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

Isomeric SMILES

C1CN2C(=NC3=CC=CC=C3C2=O)C4=C1C5=CC=CC=C5N4

WGK Germany

3

PubChem CID

65752

UN Number

2811

Molecular Weight

287.32

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (2 Activities)

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP1B1 Tchem Cytochrome P450 1B1 (2 Activities)

Discover Target: CYP1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (2 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP1A1 Tchem Cytochrome P450 1A1 (1 Activities)

Discover Target: CYP1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 32 mg/mL (96.28 mM); Water: Insoluble; Ethanol: Insoluble
• Melt Point(°C): 262 °C