Saralasin TFA - ≥98% , CAS No.S658680

CAS: S658680 Cat. No.: S658680 Molecular Weight: 1026.07

GRADE & PURITY ≥98%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Saralasin ([Sar1,Ala8] Angiotensin II) TFA is an octapeptide analog of angiotensin II. Saralasin TFA is a competitive angiotensin II receptor antagonist with a K i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Sa

Appearance:Solid

IC50& Target:Ki: 0.32 nM (Angiotensin II receptor)

In Vitro:Saralasin TFA (1 nM, 48 or 72 h) inhibits cell growth in 3T3 and SV3T3 cells. Saralasin TFA (5 μM, 2h) restores I to, fast (Fast-Inactivating Transient Outward K+ Current in Mouse Ventricle) and I K, slow (Slow-Inactivating Transient Outward K+ Curre

In Vivo:Saralasin TFA (intravenous injection, 5-50 μg/kg, a single dose) ameliorates the oxidative stress and tissue injury in cerulein-induced pancreatitis. Saralasin TFA (subcutaneous injection, 10 and 30mg/kg, a single dose) increases serum renin activit

Biological Activity:Saralasin ([Sar1,Ala8] Angiotensin II) TFA is an octapeptide analog of angiotensin II. Saralasin TFA is a competitive angiotensin II receptor antagonist with a K i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Sa

Specifications

Specifications & Purity

≥98%

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Molecular Weight: 1026.07

Chemical and Physical Properties

• Solubility: H2O : 100 mg/mL (97.46 mM; Need ultrasonic) DMSO : 50 mg/mL (48.73 mM; Need ultrasonic)