SB 706504 - Moligand™, ≥98% , CAS No.911110-38-8

CAS: 911110-38-8 Cat. No.: S287825 Molecular Weight: 492.46

GRADE & PURITY Moligand™, ≥98%

Synonyms

N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Overview

SB 706504 is a potent p38 MAPK inhibitor that inhibits Lipopolysaccharides (HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD).

Specifications

Synonyms

N-Cyano-N'-[2-[[8-(2, 6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7, 8-dihydro-7-oxopyrido[2, 3-d]pyrimidin-2-yl]amino]ethyl]guanidine

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

p38 MAPK inhibitor. Inhibits LPS-induced transcription of a range of chemokines and cytokines in chronic obstructive pulmonary disease (COPD) monocyte derived macrophages (MDMs). Also inhibits LPS-induced protein expression of IL-6, IL-10, TNFαandγ-induci

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: N=C(NC#N)NCCNC1=NC(C4=C(C)C=C(F)C=C4)=C(C=CC(N2C3=C(F)C=CC=C3F)=O)C2=N1
• InChIKey: ZQFBVJBAWLZLOM-UHFFFAOYSA-N
• Isomeric SMILES: CC1=C(C=CC(=C1)F)C2=C3C=CC(=O)N(C3=NC(=N2)NCCN=C(N)NC#N)C4=C(C=CC=C4F)F
• Molecular Weight: 492.46
• Reaxy-Rn: 51295675
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=51295675&ln=

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 49.25, Max Conc. mM: 100