Stromatoxin 1, Acetate (ScTx1), Gating inhibitor of K v2.1;Gating inhibitor of K v2.2, CAS No.741738-59-0, Gating inhibitor of K v2.1;Gating inhibitor of K v2.2

CAS: 741738-59-0 Cat. No.: rp174956 Formula: C₁₅₆H₂₃₇N₄₉O₄₈S₇ Molecular Weight: 3791.31

GRADE & PURITY BioReagent, Moligand™, ≥95%(HPLC)

Accession #

P60991

Overview

Stromatoxin 1 (ScTx1)  has been isolated from the venom of the African tarantula Stromatopelma calceatum. Stromatoxin-1 is a 34 amino-acid long peptide that belongs to the structural family of inhibitor cystine knot peptides reticulated by three disulfide bridges. It has an amidated C-terminus and bears strong homology with hanatoxin 1 (83%). Stromatoxin-1 inhibits with high affinities Kv2.1 and Kv2.2, that encode delayed K⁺ channels (respectively, with IC₅₀ of 12 and 21 nM). The block is voltage-dependent and slowly reversible. Stromatoxin-1 is also a very sensitive inhibitor of Kv4.2, that encodes a transient K⁺ current (IC₅₀ of 1.2 nM). Here also, the block is voltage-dependent indicating that ScTx-1 acts as a gating modifier rather than a pore blocker. Reversibility is faster on Kv4.2 channels. In contrast, Stromatoxin-1 has no effect on Kv1.1, Kv1.2, Kv1.3, Kv1.4, Kv1.5, Kv1.6 or Kv3.4 channels. The toxin has also no effect on voltage-dependent Na⁺ and Ca²⁺ channels of cerebellar granule cells. Stromatoxin-1 was found to increase the spontaneous phasic contraction amplitude, muscle force and tone in isolated rat urinary bladder smooth muscle. It also enhances myogenic constriction in pressurized arterial segments.

Source: Synthetic

Formula: C₁₅₆H₂₃₇N₄₉O₄₈S₇ (free base)

Molecular Weight: 3791.31 (free base)

Sequence: Asp-Cys-Thr-Arg-Met-Phe-Gly-Ala-Cys-Arg-Arg-Asp-Ser-Asp-Cys-Cys-Pro-His-Leu-Gly-Cys-Lys-Pro-Thr-Ser-Lys-Tyr-Cys-Ala-Trp-Asp-Gly-Thr-Ile-NH2 (Disulfide bridge: Cys2-Cys16, Cys9-Cys21, Cys15-Cys28)

Specifications

Product Name

Stromatoxin 1, Acetate (ScTx1), Gating inhibitor of K v2.1;Gating inhibitor of K v2.2, CAS No.741738-59-0

Synonyms

Kappa-theraphotoxin-Sc1a | κ‑theraphotoxin‑Sc1a | κ‑TRTX‑Sc1a | stromatoxin-1 | ScTx-1

Grade

BioReagent, Moligand™

Specifications & Purity

BioReagent,Moligand™,≥95%(HPLC)

Biochemical and Physiological Mechanisms

Acts as a gating-modifier to inhibit voltage-gated potassium channels. It inhibits delayed Kv2.1/KCNB1 (IC50 is 12.7 nM), Kv2.1/Kv9.3 (IC50 is 7.2 nM) (KCNB1/KCNS3), Kv2.2/KCNB2 (IC50 is 21.4 nM), and transient Kv4.2/KCND2 (IC50 is 1.2 nM) channels. Misce

Amino Acids

1-34 aa

Sequence

DCTRMFGACRRDSDCCPHLGCKPTSKYCAWDGTI-NH2 (Disulfide bridge: Cys2-Cys16, Cys9-Cys21, Cys15-Cys28)

Accession #

P60991

Predicted molecular weight

3791.31(free base)

Action Type

GATING INHIBITOR

Mechanism of action

Gating inhibitor of K v2.1;Gating inhibitor of K v2.2

CAS

741738-59-0

Molecule Type

Peptide

Storage and Shipping

Storage

Protected from light,Store at -20°C,Desiccated,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

Store at -20℃ long term. Avoid freeze/thaw cycle. Store in the dark. Desiccated.

Associated Targets(Human)

KCNB1 Tclin Potassium voltage-gated channel subfamily B member 1 (0 Activities)

Discover Target: KCNB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNB2 Tclin Potassium voltage-gated channel subfamily B member 2 (0 Activities)

Discover Target: KCNB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Genetic information

• Alternate Names: Kappa-theraphotoxin-Sc1a | κ‑theraphotoxin‑Sc1a | κ‑TRTX‑Sc1a | stromatoxin-1 | ScTx-1
• Reference:
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Frequently Asked Questions

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This product is supplied at ≥95% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

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How should this product be stored?

Store at ?20 °C, protected from light, desiccated. Avoid repeated freeze–thaw cycles. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

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What are the CAS number, molecular formula and molecular weight?

The CAS Number is 741738-59-0.

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