SGC-CBP30 - Moligand™, 10mM in DMSO , Inhibitor of CREB binding protein;Inhibitor of E1A binding protein p300, CAS No.1613695-14-9, Inhibitor of CREB binding protein;Inhibitor of E1A binding protein p300

CAS: 1613695-14-9 Cat. No.: S408055 Formula: C₂₈H₃₃ClN₄O₃ Molecular Weight: 509.04 EC Number: 106-820-6 PubChem CID: 72201027

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

SGC-CBP30 SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
In vitro

As a CREBBP/EP300-selective chemical probe, SGC-CBP30 shows moderate cytotoxicity in U2OS cells and HeLa cells.

In vivo

Cell Data

cell lines：A549 cells

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyms

2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of CREB binding protein;Inhibitor of E1A binding protein p300

Names and Identifiers

• Isomeric SMILES: CC1=C(C(=NO1)C)C2=CC3=C(C=C2)N(C(=N3)CCC4=CC(=C(C=C4)OC)Cl)C[C@H](C)N5CCOCC5
• PubChem CID: 72201027
• Molecular Weight: 509.04

Associated Targets(Human)

EP300 Tchem Histone acetyltransferase p300 (1 Activities)

Discover Target: EP300

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CREBBP Tchem CREB-binding protein (1 Activities)

Discover Target: CREBBP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BRD4 Tchem Bromodomain-containing protein 4 (0 Activities)

Discover Target: BRD4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)