SHIP2-IN-1 - 10mM in DMSO , CAS No.2252247-80-4

CAS: 2252247-80-4 Cat. No.: S656754 Formula: C₁₇H₁₃Cl₂FN₄O Molecular Weight: 379.2 PubChem CID: 138319691

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC 50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease

In Vitro

SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50: 2 µM (SHIP2)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC 50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Names and Identifiers

• Isomeric SMILES: C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CN=CC(=C2)C3=CN=C(N=C3)N
• PubChem CID: 138319691
• Molecular Weight: 379.2