Shz 1 - ≥98%(HPLC) , CAS No.326886-05-9

CAS: 326886-05-9 Cat. No.: S287579 Formula: C₁₃H₁₁BrN₂O₃S Molecular Weight: 355.21 EC Number: 806-202-2 PubChem CID: 135446537

GRADE & PURITY ≥98%(HPLC)

Synonyms

EN300-1212502 | MS-25546 | Z49626720 | E98660 | N'-(5-BROMO-2-HYDROXYBENZYLIDENE)BENZENESULFONOHYDRAZIDE | N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide | HY-108440 | N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]benzenesulfonohydrazi

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product description

Shz-1, a small cardiogenic molecule, induces various cardiac-specific genes including sarcomeric tropomyosin in P19CL6 cells. Shz-1 induces Nkx2.5 expression in mouse. Shz-1 activates the axolotl TPM4 promoter-driven ectopic expression in C2C12 cells.

Specifications

Synonyms

EN300-1212502 | MS-25546 | Z49626720 | E98660 | N'-(5-BROMO-2-HYDROXYBENZYLIDENE)BENZENESULFONOHYDRAZIDE | N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide | HY-108440 | N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]benzenesulfonohydrazi

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Activator of early cardiac genes (includingNkx2.5) in pluripotent stem cells. Induces phenotypic differentiation in human mobilized peripheral blood mononuclear cells. Enhances myocardial regenerative repair by stem cells in a rat myocardial cryoinjury mo

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 488202918
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202918
• Canonical Smiles: C1=CC=C(C=C1)S(=O)(=O)NN=CC2=C(C=CC(=C2)Br)O
• IUPAC Name: N-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]benzenesulfonamide
• InChIKey: OEMCLQLAWYKPRK-OQLLNIDSSA-N
• INCHI: 1S/C13H11BrN2O3S/c14-11-6-7-13(17)10(8-11)9-15-16-20(18,19)12-4-2-1-3-5-12/h1-9,16-17H/b15-9+
• Isomeric SMILES: C1=CC=C(C=C1)S(=O)(=O)N/N=C/C2=C(C=CC(=C2)Br)O
• PubChem CID: 135446537
• Molecular Weight: 355.21

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzenesulfonamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzenesulfonamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonamides
• Alternative Parents: Benzenesulfonyl compounds P-bromophenols Bromobenzenes 1-hydroxy-2-unsubstituted benzenoids Sulfonohydrazides Hydrazinosulfonyl compounds Aryl bromides Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organobromides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Benzenesulfonamide - Benzenesulfonyl group - 4-halophenol - 4-bromophenol - Bromobenzene - Halobenzene - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Sulfonohydrazide - Hydrazinosulfonyl compound - Aryl bromide - Aryl halide - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Organic oxide - Organooxygen compound - Organonitrogen compound - Organobromide - Organohalogen compound - Organosulfur compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Candida albicans (78123 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 35.52, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 17.76, Max Conc. mM: 50
• Molecular Weight: 355.210 g/mol
• XLogP3: 2.900
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 353.967 Da
• Monoisotopic Mass: 353.967 Da
• Topological Polar Surface Area: 87.100 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 429.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1

Frequently Asked Questions

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 326886-05-9, the molecular formula is C13H11BrN2O3S, and the molecular weight is 355.21 g/mol. InChIKey OEMCLQLAWYKPRK-OQLLNIDSSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.