Sipagladenant - ≥99% , CAS No.858979-50-7

CAS: 858979-50-7 Cat. No.: S647566 Formula: C₂₀H₁₉N₃O₄S Molecular Weight: 397.45 PubChem CID: 23144148

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

Sipagladenant (Compound I) is an orally active adenosine receptor A2A inverse agonist. Sipagladenant can be used in frontal lobe dysfunction research .

In Vivo

Sipagladenant (oral administration; 0.3 mg/kg; once) treatment improves cognitive impairment due to a decline in dopamine function in the medial prefrontal cortex. Sipagladenant (oral administration; 0.1 mg/kg; once) treatment can improve alternation behavior. Sipagladenant (oral administration; 0.1 mg/kg; once) treatment can improve gait parameters. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Medial prefrontal dopaminerjic terminal-lesioned CD(SD) IGS male ratDosage: 0.3 mg/kg Administration: Oral administration; 0.3 mg/kg; once Result: Showed longer exploration time of the novel object (65.03%) than that of the familiar object (34.97%) (p<0.001). Animal Model: ICR mice with cognitive impairment and/or movement disoderDosage: 0.1 mg/kg Administration: Oral administration; 0.1 mg/kg; once Result: Showed a significantly high alternation behavior (69.5%) as compared to the vehicle administration group (59.6%) (p<0.01). Animal Model: ICR mice with cognitive impairment and/or movement disoderDosage: 0.1 mg/kg Administration: Oral administration; 0.1 mg/kg; once Result: Showed a significantly large maximum contact area and gait area of the left hindpaw as compared to the vehicle administration group (p<0.05), tendency of the maximum contact area and gait area of the right forepaw being large (p<0.1).

Form:Solid

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Sipagladenant (Compound I) is an orally active adenosine receptor A2A inverse agonist. Sipagladenant can be used in frontal lobe dysfunction research.

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC1=NC=C(C=C1)C(=O)NC2=NC(=C(S2)C(=O)C3CCOCC3)C4=CC=CO4
• Isomeric SMILES: CC1=NC=C(C=C1)C(=O)NC2=NC(=C(S2)C(=O)C3CCOCC3)C4=CC=CO4
• PubChem CID: 23144148
• Molecular Weight: 397.45

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (125.80 mM; ultrasonic and warming and heat to 60°C)

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C, protected from light, desiccated. Keep the container tightly closed with desiccant — the material is moisture-sensitive.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 858979-50-7, the molecular formula is C20H19N3O4S, and the molecular weight is 397.45 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.