SJFα - ≥99% , CAS No.2254609-27-1

CAS: 2254609-27-1 Cat. No.: S648388 Formula: C₅₉H₆₇F₂N₇O₁₁S Molecular Weight: 1120.27

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Overview

SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC 50 of 7.16  nM, but is far less effective at degrading p38δ (DC 50 =299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM

Form:Solid

IC50& Target:p38α 7.16 nM (DC 50 ) p38δ 299 nM (DC 50 ) VHL

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC 50 of 7.16u2009u2009nM, but is far less effective at degrading p38δ (DC 50 =299u2009nM) and does not degrade the other p38 isoforms (β and γ) at concentrations

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

Molecular Weight

1120.27

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (89.26 mM; ultrasonic and warming and heat to 60°C)