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SLU-PP-915 - ≥98% , CAS No.2285432-92-8
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
SLU-PP-915 is an agonist of ERR . SLU-PP-915 has an EC 50 value of approximately 400 nM for ERRα , ERRβ , and ERRγ . SLU-PP-915 has potential application in maintaining oxidative metabolism and heart failure.
Form:Solid
In Vitro:SLU-PP-915 (2.5 µM; 72 h) increases the gene and protein expression of transcription factor EB (TFEB) in neonatal rat ventricular myocytes (NRVMs). SLU-PP-915 (5 µM) increases the expression of TFEB gene (at 3 h) and TFEB protein (at 72 h) in C 2 C 12 cells. SLU-PP-915 (5 µM; 48 h or 72 h) increases the expression of PGC1a, p62, PDK4, CTSD, LAMP1, LAMP2 and MCOLN1 ERR target genes in C 2 C 12 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Neonatal rat ventricular myocytes (NRVMs) and C 2 C 12 cells. Concentration: 2.5 µM and 5 µM. Incubation Time: 72 h. Result: Increased the expression of TFEB and LAMP1. ImmunofluorescenceCell Line: C 2 C 12 cells. Concentration: 5 µM. Incubation Time: 48 h. Result: Increased the expression of TFEB.
In Vivo:SLU-PP-915 improves transaortic constriction (TAC) induced heart failure in adult male mice [1] . SLU-PP-915 significantly normalizes the metabolic profile of fatty acids/lipids and TCA/OXPHOS metabolites in the heart of mice with 6-week pressure overload. SLU-PP-915 improves the blood pumping function in vivo in TAC induced heart failure without affecting cardiac hypertrophy [2] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Males C57BI/6J mice (8 weeks of age) [2] . Dosage: 20 mg/kg. Administration: Intraperitoneal injection; single dose. Result: Pharmacokinetic (PK) parameters of SLU-PP-915 in mice T max (h) C max (ng/mL) AUC last (h•ng/mL) V z /F (L/kg) CL/F (mL/min/kg) T 1/2 (h) 0.5 2813 1846 11 179 0.71
Specifications
Specifications & Purity
≥98%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
| Canonical Smiles | O=C(C1=CC=C(C2=CC(B(O)O)=CC=C2)S1)NC3=C(F)C=CC=C3 |
|---|---|
| Molecular Weight | 341.16 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
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Look up COA →🔬 Specification Sheet
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