SLU-PP-915 - ≥98% , CAS No.2285432-92-8

CAS: 2285432-92-8 Cat. No.: S657035 Formula: C₁₇H₁₃BFNO₃S Molecular Weight: 341.16

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

SLU-PP-915 is an agonist of ERR . SLU-PP-915 has an EC 50 value of approximately 400 nM for ERRα , ERRβ , and ERRγ . SLU-PP-915 has potential application in maintaining oxidative metabolism and heart failure.

Form:Solid

In Vitro:SLU-PP-915 (2.5 µM; 72 h) increases the gene and protein expression of transcription factor EB (TFEB) in neonatal rat ventricular myocytes (NRVMs). SLU-PP-915 (5 µM) increases the expression of TFEB gene (at 3 h) and TFEB protein (at 72 h) in C 2 C 12 cells. SLU-PP-915 (5 µM; 48 h or 72 h) increases the expression of PGC1a, p62, PDK4, CTSD, LAMP1, LAMP2 and MCOLN1 ERR target genes in C 2 C 12 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Neonatal rat ventricular myocytes (NRVMs) and C 2 C 12 cells. Concentration: 2.5 µM and 5 µM. Incubation Time: 72 h. Result: Increased the expression of TFEB and LAMP1. ImmunofluorescenceCell Line: C 2 C 12 cells. Concentration: 5 µM. Incubation Time: 48 h. Result: Increased the expression of TFEB.

In Vivo:SLU-PP-915 improves transaortic constriction (TAC) induced heart failure in adult male mice [1] . SLU-PP-915 significantly normalizes the metabolic profile of fatty acids/lipids and TCA/OXPHOS metabolites in the heart of mice with 6-week pressure overload. SLU-PP-915 improves the blood pumping function in vivo in TAC induced heart failure without affecting cardiac hypertrophy [2] . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Males C57BI/6J mice (8 weeks of age) [2] . Dosage: 20 mg/kg. Administration: Intraperitoneal injection; single dose. Result: Pharmacokinetic (PK) parameters of SLU-PP-915 in mice T max (h) C max (ng/mL) AUC last (h•ng/mL) V z /F (L/kg) CL/F (mL/min/kg) T 1/2 (h) 0.5 2813 1846 11 179 0.71

Specifications

Specifications & Purity

≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: O=C(C1=CC=C(C2=CC(B(O)O)=CC=C2)S1)NC3=C(F)C=CC=C3
• Molecular Weight: 341.16

Frequently Asked Questions

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2285432-92-8, the molecular formula is C17H13BFNO3S, and the molecular weight is 341.16 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.