SN-38 glucuronide - Moligand™, 10 mM in DMSO , CAS No.121080-63-5

CAS: 121080-63-5 Cat. No.: S1495784 Formula: C₂₈H₂₈N₂O₁₁ Molecular Weight: 568.53 PubChem CID: 443154

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O
• PubChem CID: 443154
• Molecular Weight: 568.53

Chemical and Physical Properties

• Refractive Index: n20D1.75 (Predicted)
• Boil Point(°C): 1019.70° C at 760 mmHg (Predicted)
• Melt Point(°C): >250°C (lit.)(dec.)

References

1. Xin Lv, Zhe Wang, Zhen Wang, Hang Yin, Yangliu Xia, Lili Jiang, Yong Liu.  (2023)  Drug-drug interaction potentials of tucatinib inhibition of human UDP-glucuronosyltransferases.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:37263554] [10.1016/j.cbi.2023.110574]

2. Shichao Xiao, Hang Yin, Xin Lv, Zhen Wang, Lili Jiang, Yangliu Xia, Yong Liu.  (2024)  Inhibition of human UDP-glucuronosyltransferase (UGT) enzymes by darolutamide: Prediction of in vivo drug-drug interactions.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:39278459] [10.1016/j.cbi.2024.111246]

Frequently Asked Questions

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 121080-63-5, the molecular formula is C28H28N2O11, and the molecular weight is 568.53 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.